CAS 70161-11-4

Ivermectin B1a

Description:

Ivermectin B1a, with the CAS number 70161-11-4, is a macrocyclic lactone compound that is primarily used as an antiparasitic agent. It is derived from the fermentation of the soil bacterium Streptomyces avermitilis. This compound exhibits a broad spectrum of activity against various parasites, including nematodes and ectoparasites, making it valuable in both veterinary and human medicine. Ivermectin B1a functions by binding to specific chloride channels, leading to paralysis and death of the parasites. It is characterized by its lipophilic nature, which allows for effective absorption and distribution in biological systems. The compound is typically administered orally or topically, depending on the target organism and application. Ivermectin B1a is known for its relatively low toxicity in mammals, which contributes to its widespread use. However, it is essential to use this compound judiciously to prevent the development of resistance among target parasites. Overall, Ivermectin B1a plays a crucial role in managing parasitic infections in various species.

Formula: C₄₈H₇₄O₁₄

InChI: InChI=1/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12-,27-15-,32-14-/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key: InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES: O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]

Synonyms:

• Avermectin A1a, 5-O-demethyl-22,23-dihydro-
• 22,23-Dihydroavermectin B1a
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv.
• Dihydroavermectin B1a
• 5-O-Demethyl-22,23-dihydroavermectin A1a

Ivermectin

CAS: 70161-11-4

Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.

Formula: C₄₈H₇₄O₁₄

Purity: 85%Min

Molecular weight: 875.1 g/mol

Ref: 3D-VCA16111