Pertussis toxin, produced by the bacterium Bordetella pertussis, is a potent virulence factor responsible for the pathogenicity of whooping cough. It is a multi-subunit protein composed of five distinct components, which include an enzymatically active A subunit and four B subunits that facilitate binding to host cells. The toxin functions primarily by ADP-ribosylating G proteins, leading to dysregulation of cellular signaling pathways, which ultimately results in increased mucus production and impaired immune responses. Pertussis toxin is known to induce a range of biological effects, including lymphocytosis and modulation of cytokine release. It is also a key component in acellular pertussis vaccines, where it is used to elicit an immune response without causing disease. The CAS number 70323-44-3 specifically identifies this toxin, which is crucial for research and clinical applications. Overall, pertussis toxin is significant not only for its role in disease but also for its utility in vaccine development and immunological studies.

pertussis toxin from bordetella per-tussis

70323-44-3: Pertussis toxin, produced by the bacterium Bordetella pertussis, is a potent virulence factor responsible for the pathogenicity of whooping cough. It is a multi-subunit protein composed of five distinct components, which include an enzymatically active A subunit and four B subunits that facilitate binding to host cells. The toxin functions primarily by ADP-ribosylating G proteins, leading to dysregulation of cellular signaling pathways, which ultimately results in increased mucus production and impaired immune responses. Pertussis toxin is known to induce a range of biological effects, including lymphocytosis and modulation of cytokine release. It is also a key component in acellular pertussis vaccines, where it is used to elicit an immune response without causing disease. The CAS number 70323-44-3 specifically identifies this toxin, which is crucial for research and clinical applications. Overall, pertussis toxin is significant not only for its role in disease but also for its utility in vaccine development and immunological studies.

CAS 70323-44-3

pertussis toxin from bordetella per-tussis

PERTUSSIS TOXIN BRP

Ref: 41-Y0000021