CAS 70384-29-1: peplomycin sulfate

Description: Peplomycin sulfate is an antitumor antibiotic derived from the fermentation of the bacterium Streptomyces verticillus. It is primarily used in cancer treatment, particularly for certain types of tumors, due to its ability to inhibit DNA synthesis and induce apoptosis in cancer cells. The compound exhibits a unique structure characterized by a cyclic peptide linked to a sugar moiety, which contributes to its biological activity. Peplomycin sulfate is known for its relatively low toxicity compared to other chemotherapeutic agents, making it a valuable option in cancer therapy. It is typically administered via injection and has been studied for its efficacy against various malignancies, including squamous cell carcinoma and testicular cancer. The compound's mechanism of action involves intercalation into DNA, leading to strand breaks and ultimately cell death. As with many chemotherapeutic agents, monitoring for side effects is essential, as it can cause myelosuppression and other adverse reactions. Overall, peplomycin sulfate represents a significant tool in the oncological pharmacotherapy arsenal.

Formula: C₆₁H₉₀N₁₈O₂₅S₃

InChI: InChI=1S/C61H88N18O21S2.H2O4S/c1-24-39(76-52(79-50(24)64)31(16-37(63)83)71-17-30(62)51(65)89)56(93)78-41(47(32-18-67-23-72-32)98-60-49(45(87)43(85)35(19-80)97-60)99-59-46(88)48(100-61(66)95)44(86)36(20-81)96-59)57(94)73-27(4)42(84)25(2)53(90)77-40(28(5)82)55(92)70-15-12-38-74-34(22-101-38)58-75-33(21-102-58)54(91)69-14-9-13-68-26(3)29-10-7-6-8-11-29;1-5(2,3)4/h6-8,10-11,18,21-23,25-28,30-31,35-36,40-49,59-60,68,71,80-82,84-88H,9,12-17,19-20,62H2,1-5H3,(H2,63,83)(H2,65,89)(H2,66,95)(H,67,72)(H,69,91)(H,70,92)(H,73,94)(H,77,90)(H,78,93)(H2,64,76,79);(H2,1,2,3,4)/t25-,26-,27+,28+,30-,31-,35-,36+,40-,41-,42-,43+,44+,45-,46-,47-,48-,49-,59+,60-;/m0./s1

InChI key: InChIKey=ZHHIHQFAUZZMTG-BSVJBJGJSA-N

SMILES: O=C(OC1C(O)C(OC(CO)C1O)OC2C(OC(C3=CN=CN3)C(NC(=O)C=4N=C(N=C(N)C4C)C(NCC(N)C(=O)N)CC(=O)N)C(=O)NC(C)C(O)C(C(=O)NC(C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCNC(C=7C=CC=CC7)C)C(O)C)C)OC(CO)C(O)C2O)N.O=S(=O)(O)O

Synonyms:

• 2-({2-[2-{[(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)carbonyl]amino}-3-[(3-hydroxy-5-{[3-hydroxy-1-oxo-1-({2-[4-({3-[(1-phenylethyl)amino]propyl}carbamoyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)butan-2-yl]amino}-4-methyl-5-oxopentan-2-yl)amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl}oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate sulfate (1:1) (non-preferred name)
• 3-((S)-1'-Phenylethylamino)propylamino-bleomycin sulfate
• Bleomycinamide, N(sup 1)-(3-((1-phenylethyl)amino)propyl)-, (S)-, sulfate (1:1) (salt)
• Bleomycinamide, N1-(3-((1-phenylethyl)amino)propyl)-, (S)-, sulfate (1:1) (salt)
• Bleomycinamide, N¹-[3-[(1-phenylethyl)amino]propyl]-, (S)-, sulfate (1:1) (salt)
• Bleomycinamide, N¹-[3-[(1-phenylethyl)amino]propyl]-, sulfate (1:1)
• Bleomycinamide, N¹-[3-[[(1S)-1-phenylethyl]amino]propyl]-, sulfate (1:1) (salt)
• Ccris 2471
• N(sup 1)-(3-(((S)-(alpha-Methylbenzyl))amino)propyl)bleomycinamide sulfate (1:1) (salt)
• Nk 631
• Nsc 276382
• Pepleo
• Pepleomycin sulfate
• Peplomycin sulfate [USAN:JAN]
• Peplomycin sulfate salt

Peplomycin sulfate

CAS: 70384-29-1

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• Formula: C₆₁H₉₀N₁₈O₂₅S₃
• Purity: Min. 95%
• Molecular weight: 1,571.67 g/mol