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CAS 70476-82-3

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Mitoxantrone hydrochloride

Description:
Mitoxantrone hydrochloride is a synthetic anthracenedione derivative primarily used as an antineoplastic agent in the treatment of certain cancers, including breast cancer and leukemia, as well as in multiple sclerosis. It exhibits a blue color and is characterized by its ability to intercalate DNA, thereby inhibiting topoisomerase II, which disrupts DNA replication and transcription. This mechanism contributes to its cytotoxic effects on rapidly dividing cells. Mitoxantrone hydrochloride is soluble in water and exhibits a moderate lipophilicity, which influences its distribution in biological systems. The compound is typically administered intravenously and is known for its potential side effects, including cardiotoxicity, myelosuppression, and gastrointestinal disturbances. Its pharmacokinetics involve hepatic metabolism and renal excretion, necessitating careful monitoring during treatment. Overall, Mitoxantrone hydrochloride is a potent chemotherapeutic agent with specific applications and associated risks that require thorough understanding and management in clinical settings.
Formula:C22H28N4O6·2ClH
InChI:InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChI key:InChIKey=ZAHQPTJLOCWVPG-UHFFFAOYSA-N
SMILES:N(CCNCCO)C1=C2C(=C(NCCNCCO)C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O.Cl
Synonyms:
  • 1,4-Dihydroxy-5,8-Bis({2-[(2-Hydroxyethyl)Amino]Ethyl}Amino)Anthracene-9,10-Dione Dihydrochloride
  • 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, dihydrochloride
  • 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, hydrochloride (1:2)
  • Bisantrone
  • Cl 232315
  • Immunex
  • Mitoxantrone dihydrochloride
  • Mitoxantrone hcl
  • NSC 301739
  • Nci 301739
  • See more synonyms
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