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CAS 70774-25-3

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Leurubicin

Description:
Leurubicin is an anthracycline antibiotic that is primarily used in cancer therapy, particularly for treating various types of leukemia and solid tumors. It is structurally related to doxorubicin and exhibits similar mechanisms of action, primarily by intercalating into DNA and inhibiting topoisomerase II, which disrupts DNA replication and transcription. This leads to apoptosis in rapidly dividing cancer cells. Leurubicin is known for its potent antitumor activity, but like other anthracyclines, it can also cause significant side effects, including cardiotoxicity and myelosuppression. Its pharmacokinetics involve metabolism primarily in the liver, and it is excreted through the bile and urine. The compound's efficacy and safety profile make it a subject of ongoing research, particularly in combination therapies to enhance its therapeutic effects while minimizing adverse reactions. As with any chemotherapeutic agent, careful monitoring and management of side effects are essential during treatment.
Formula:C33H40N2O12
InChI:InChI=1/C33H40N2O12/c1-13(2)8-17(34)32(43)35-18-9-22(46-14(3)27(18)38)47-20-11-33(44,21(37)12-36)10-16-24(20)31(42)26-25(29(16)40)28(39)15-6-5-7-19(45-4)23(15)30(26)41/h5-7,13-14,17-18,20,22,27,36,38,40,42,44H,8-12,34H2,1-4H3,(H,35,43)/t14-,17-,18-,20-,22-,27+,33-/m0/s1
Synonyms:
  • Leurubicin [INN]
  • N-Leucyldoxorubicin
  • (8S,10S)-10-((3-((S)-2-Amino-4-methylvaleramido)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
  • Leurubicina
  • Leurubicina [INN-Spanish]
  • Leurubicine
  • Leurubicine [INN-French]
  • Leurubicinum
  • Leurubicinum [INN-Latin]
  • Unii-1Z20Mgk851
  • (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-lyxo-hexopyranoside
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