CAS 7083-71-8

Emetine, dihydrochloride, hydrate

Description:

Emetine dihydrochloride hydrate is a chemical compound derived from the plant Cephaelis ipecacuanha, commonly known for its use in medicine, particularly as an emetic and an antiamoebic agent. It is characterized by its molecular formula, which includes two hydrochloride ions and water molecules in its hydrated form. The compound typically appears as a white to off-white crystalline powder and is soluble in water, which facilitates its use in various pharmaceutical formulations. Emetine acts by inhibiting protein synthesis, making it effective against certain protozoan infections, such as amoebic dysentery. However, it is important to note that emetine can have significant side effects, including cardiotoxicity and gastrointestinal disturbances, which necessitate careful dosing and monitoring in clinical settings. Due to its potential toxicity, the use of emetine has declined in favor of safer alternatives, but it remains a subject of interest in research for its unique pharmacological properties.

Formula: C₂₉H₄₀N₂O₄·2ClH·xH₂O

InChI: InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1

InChI key: InChIKey=IZTPMTAWOCEKKM-VXMYZLRESA-N

SMILES: C([C@H]1C[C@]2(C=3C(=CC(OC)=C(OC)C3)CCN2C[C@@H]1CC)[H])[C@@H]4C=5C(=CC(OC)=C(OC)C5)CCN4.Cl.O

Synonyms:

• 2H-Benzo[a]quinolizine, 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, hydrochloride, hydrate (1:2:?), (2S,3R,11bS)-
• 2H-Benzo[a]quinolizine, emetan deriv.
• Emetan, 6′,7′,10,11-tetramethoxy-, dihydrochloride, hydrate
• Emetine Dihydrochloride Hydrate
• Emetine hydrochloride hydrate

Emetine Hydrochloride

CAS: 7083-71-8

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Formula: C₂₉H₄₀N₂O₄·2HCl·xH₂O

Color and Shape: White Off-White Powder

Molecular weight: 553.56 (anhydrous)

Ref: 45-1235004

Emetine Hydrochloride Hydrate

Controlled Product

CAS: 7083-71-8

Applications Hydrochloride salt of Emetine (E521535) is the principal alkaloid of ipecac, the ground roots of Uragoga ipecacuanha.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nomura, T. et. al.: J. Biol. Chem. 285, 7722 (2010)

Formula: C₂₉H₄₀N₂O₄·2ClH·H₂O

Color and Shape: Neat

Molecular weight: 571.58

Ref: TR-E521535