CAS 70838-44-7

5'-O-Benzoyl-2,3'-anhydrothymidine

Description:

5'-O-Benzoyl-2,3'-anhydrothymidine is a modified nucleoside derivative of thymidine, characterized by the presence of a benzoyl group at the 5' position and an anhydro structure between the 2' and 3' positions. This compound is typically used in biochemical research and synthetic applications due to its unique structural features, which can influence its reactivity and interaction with biological molecules. The benzoyl group enhances lipophilicity, potentially improving membrane permeability, while the anhydro configuration can affect the stability and conformation of the nucleoside. As a nucleoside analog, it may exhibit interesting properties in terms of nucleic acid interactions, making it a valuable tool in studies related to DNA and RNA synthesis, as well as in the development of antiviral or anticancer agents. Its CAS number, 70838-44-7, allows for precise identification in chemical databases and literature. Overall, 5'-O-Benzoyl-2,3'-anhydrothymidine serves as an important compound in the field of medicinal chemistry and molecular biology.

Formula: C₁₇H₁₆N₂O₅

InChI: InChI=1/C17H16N2O5/c1-10-8-19-14-7-12(24-17(19)18-15(10)20)13(23-14)9-22-16(21)11-5-3-2-4-6-11/h2-6,8,12-14H,7,9H2,1H3/t12-,13+,14+/m0/s1

Synonyms:

• 2,5-Methano-5H, 9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,3-[(benzoyloxy)methyl]-2,3-dihydro-8-methyl-, (2R, 3R, 5R)-

5''-O-Benzoyl-2,3''-anhydrothymidine

CAS: 70838-44-7

Ref: 7W-GN3910

5'-O-Benzoyl-2,3'-anhydrothymidine

CAS: 70838-44-7

5'-O-Benzoyl-2,3'-anhydrothymidine is a heterocycle that has been shown to have immunosuppressive properties. The compound binds to the immunodeficiency virus by covalent binding to an isomeric site on the viral envelope protein. It has been shown that 5'-O-Benzoyl-2,3'-anhydrothymidine can inhibit the growth of HIV in vitro with a 50% inhibitory concentration (IC50) of 0.8 μM. This compound also displays potent antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2).

Formula: C₁₇H₁₈N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 330.34 g/mol

Ref: 3D-NB03505

5'-O-Benzoyl-2,3'-anhydrothymidine-d3

Controlled Product

CAS: 70838-44-7

Applications An intermediate in the preparation of labelled anti-HIV pharmaceuticals
References Naimi, E., et al.: J. Med. Chem., 46, 995 (2003),

Formula: C₁₇D₃H₁₃N₂O₅

Color and Shape: Neat

Molecular weight: 331.338

Ref: TR-B207982

5'-O-Benzoyl-2,3'-anhydrothymidine

Controlled Product

CAS: 70838-44-7

Applications An intermediate in the preparation of anti-HIV pharmaceuticals
References Naimi, E., et al.: J. Med. Chem., 46, 995 (2003),

Formula: C₁₇H₁₆N₂O₅

Color and Shape: Neat

Molecular weight: 328.32

Ref: TR-B207980