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CAS 7085-44-1

:

Chlorothiazide sodium

Description:
Chlorothiazide sodium is a thiazide diuretic, primarily used in the treatment of hypertension and edema associated with various conditions, such as heart failure. It is a sodium salt of chlorothiazide, which enhances its solubility and bioavailability. The compound functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, thereby reducing blood volume and blood pressure. Chlorothiazide sodium is typically administered orally and is known for its relatively rapid onset of action. In terms of physical properties, it is a white to off-white crystalline powder, soluble in water, and has a specific melting point range. The substance may also exhibit side effects, including electrolyte imbalances, dehydration, and potential allergic reactions. As with any medication, it is essential to use chlorothiazide sodium under medical supervision to monitor for efficacy and adverse effects.
Formula:C7H6ClN3O4S2·Na
InChI:InChI=1S/C7H6ClN3O4S2.Na/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-3H,(H,10,11)(H2,9,12,13);
InChI key:InChIKey=KEQIGINJIBISIL-UHFFFAOYSA-N
SMILES:O=S1(=O)C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NC=N1.[Na]
Synonyms:
  • 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide, monosodium salt
  • Sodium chlorothiazide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, sodium salt (1:1)
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, monosodium salt
  • Chlorothiazide sodium
  • Chlorothiazide sodium [USAN]
  • Sodium diuril
  • 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide, sodium deriv.
  • sodium 6-chloro-7-sulfamoyl-1,2,4-benzothiadiazin-2-ide 1,1-dioxide
  • Diuril
  • See more synonyms
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