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CAS 70968-93-3

:

8-HETE

Description:
8-HETE, or 8-hydroxyeicosatetraenoic acid, is a bioactive lipid derived from arachidonic acid, a polyunsaturated fatty acid. It is classified as a hydroxyeicosanoid, which plays a significant role in various physiological processes, including inflammation and cell signaling. The compound is known for its involvement in the modulation of vascular tone and platelet aggregation, making it relevant in cardiovascular research. 8-HETE is produced through the action of lipoxygenase enzymes, which catalyze the oxidation of arachidonic acid. Its structure features a hydroxyl group at the 8-position of the eicosatetraenoic acid backbone, contributing to its reactivity and biological activity. The substance is typically studied in the context of its potential roles in disease mechanisms, particularly in inflammatory conditions and cancer. Due to its complex interactions within biological systems, 8-HETE is of interest in pharmacological research aimed at developing therapeutic agents targeting lipid-mediated pathways.
Formula:C20H32O3
InChI:InChI=1/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,14-11-,16-13+
InChI key:InChIKey=NLUNAYAEIJYXRB-HEJOTXCHNA-N
SMILES:C(C/C=C\CCCC(O)=O)(/C=C/C=C\C/C=C\CCCCC)O
Synonyms:
  • 8-HETE
  • (5Z,9E,11Z,14Z)-8-Hydroxy-5,9,11,14-eicosatetraenoic acid
  • 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, (E,Z,Z,Z)-
  • 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, (5Z,9E,11Z,14Z)-
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