CAS 71-63-6

Digitoxin

Description:

Digitoxin is a cardiac glycoside derived from the plant Digitalis purpurea, commonly known as foxglove. It is primarily used in the treatment of heart conditions, particularly in cases of heart failure and atrial fibrillation, due to its ability to increase the force of cardiac contractions and regulate heart rhythm. The chemical structure of digitoxin includes a steroid nucleus with a lactone ring and multiple sugar moieties, which contribute to its pharmacological properties. It is lipophilic, allowing it to cross cell membranes easily, and has a relatively long half-life, which necessitates careful monitoring of dosage to avoid toxicity. Common side effects include gastrointestinal disturbances, visual changes, and potential arrhythmias, particularly in cases of overdose. Digitoxin's mechanism of action involves the inhibition of the Na+/K+ ATPase pump, leading to increased intracellular calcium levels, which enhances cardiac contractility. Due to its narrow therapeutic index, digitoxin requires careful dosing and monitoring in clinical settings.

Formula: C₄₁H₆₄O₁₃

InChI: InChI=1/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27?,28?,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

InChI key: InChIKey=WDJUZGPOPHTGOT-XUDUSOBPSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C=8COC(=O)C8)[H])[H]

Synonyms:

• (3beta,5beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3β,5β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14-Hydroxycard-20(22)-Enolide
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Cardidigin
• Cardigin
• Carditoxin
• Coramedan
• Cristapurat
• Crystalline digitalin
• Crystodigin
• Digicor
• Digilong
• Digimed
• Digimerck
• Digipural
• Digisidin
• Digitaline Nativelle
• Digitophyllin
• Digitoxigenin tridigitoxoside
• Digitoxina
• Digitoxine
• Digitoxoside
• Digitrin
• Ditaven
• Glucodigin
• Lanatoxin
• Myodigin
• Nsc 7529
• Purodigin
• Purpurid
• Tradigal
• Unidigin
• Digitoxin
• (3β,5β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• Digitoksin
• Acedoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• mono-digitoxid
• monodigitoxoside
• Card-20(22)-enolide,3-[(O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• .4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• 4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3b,5b)-
• digitoxigenin-tridigitoxosid
• Tri-digitoxoside
• digitalinecristallisee
• (3beta,5beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-card-20(22)-enolide
• DIGITALIN
• Purodigin, crystalline
• 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• digitoksim
• Digitoxin ,>=95%
• Digitaline cristallisee
• Digtoxoside
• hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-
• digitoxinum
• digitoxigenintridigitoxoside
• 6-dideoxy-beta-d-ribo-o-6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-2
• Tardigal
• Digitoxin (8CI)
• hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-beta-D-ribo-hexopyranosyl
• digitalin,crystalline
• Digitoxin,5β,20(22)-Cardenolide-3β,14-diol-3-(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy
• ta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-14-hy
• Digitogenin
• Digitoxin solution
• mono-glycocard
• Cristodigin
• (3beta,5beta)-y)-14-hydroxy
• 4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• 5beta-Card-20(22)-enolide, 3beta,14-dihydroxy-, 3-(tris-(digitoxoside))
• (3beta,5beta)-3-((o-2,6-dideoxy-beta-d-ribohexopyranosyl-(1-4)-o-2,6-dideoxy-be
• 3-((2,6-Dideoxy-4-O-[2,6-dideoxy-4-O-(2,6-dideoxyhexopyranosyl)hexopyranosyl]hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-(O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy-14-hydroxy-, (3.beta.,5.beta.)-
• carditalin
• digitalinenativelle
• hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• DIGITOXIN CRYSTALLINE
• Digitalinum verum
• 5β,20(22)-cardenolide-3β,14-diol-3-(o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-d-ribo-hexopyranosyl)oxy
• Digitoxin,99%
• Digitoxoside (7CI)
• (3beta,5beta)-hexopyranosyl)oxy]-14-hydroxy
• Digitoxin (200 mg)
• Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-
• .4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• De-Tone
• (3,5)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• Natigal
• DIGITOXIN,USP
• asthenthilo
• 3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-card-20(22)-enolid
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-
• DIGITOXIN(P)
• 20(22),5BETA-CARDENOLID-3BETA,14BETA-DIOL 3BETA-2,6-DIDEOXY-(4->O)-[2,6-DIDEOXY-4(4->O)-(2,6-DIDEOXY-BETA-D-RIBOHEXOPYRANOSYL)-BETA-D-RIBOHEXOPYRANOSID]
• 5BETA,20[22]-CARDENOLIDE-3BETA,14-DIOL-3[O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL]OXY
• (3b,5b)-3-[(O-2,6-Dideoxy-b-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• digitalinumverum

Digitoxin

CAS: 71-63-6

Digitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₄₁H₆₄O₁₃

Purity: (HPLC) ≥98%

Color and Shape: Powder

Molecular weight: 764.96

Ref: 11-0814S

Digitoxin

CAS: 71-63-6

Digitoxin

Formula: C₄₁H₆₄O₁₃

Purity: 97.9%

Color and Shape: Off-White

Molecular weight: 764.43469

Ref: 47-855

DIGITOXIN RS

CAS: 71-63-6

DIGITOXIN RS

Formula: C₄₁H₆₄O₁₃

Molecular weight: 764.9391

Ref: 41-ICRS0288

DIGITOXIN FOR LC ASSAY CRS

CAS: 71-63-6

DIGITOXIN FOR LC ASSAY CRS

Ref: 41-Y0002036

DIGITOXIN CRS

CAS: 71-63-6

DIGITOXIN CRS

Formula: C₄₁H₆₄O₁₃

Color and Shape: Powder. White. Whitish.

Molecular weight: 764.9391

Ref: 41-D1800000

Digitoxin

CAS: 71-63-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₄₁H₆₄O₁₃

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 764.94 g/mol

Ref: 45-1199002

Digitoxin

CAS: 71-63-6

Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM).

Formula: C₄₁H₆₄O₁₃

Purity: 98.23% - 98.54%

Color and Shape: Very Small Elongated Rectangular Plates From Dilute Alcohol 1998)

Molecular weight: 764.94

Ref: TM-T0295

Digitoxin

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Molecular weight: 764.94

Ref: 7W-GC5627

Digitoxin (Digoxin EP Impurity A)

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Color and Shape: White To Off-White Solid

Molecular weight: 764.95

Ref: 4Z-D-461

Digitoxin

Controlled Product

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Color and Shape: Neat

Molecular weight: 764.94

Ref: 04-C12633800

Digitoxin 100 µg/mL in Acetonitrile

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Color and Shape: Single Solution

Molecular weight: 764.94

Ref: 04-A12633800AL-100

Digitoxin

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 764.95

Ref: 3B-D0542

Digitoxin

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Purity: 95%~99%

Molecular weight: 764.95

Ref: BP-BP0489

Digitoxin

CAS: 71-63-6

Digitalis glycoside

Formula: C₄₁H₆₄O₁₃

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 764.95

Ref: 5G-82516

Digitoxin-21,23,23-d3

Controlled Product

CAS: 71-63-6

Applications Isotope labelled Digitoxin (D445950), is used as a cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Formula: C₄₁H₆₁D₃O₁₃

Purity: 90%

Color and Shape: Neat

Molecular weight: 767.96

Ref: TR-D445952

Digitoxin

CAS: 71-63-6

Stability Hygroscopic
Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Formula: C₄₁H₆₄O₁₃

Color and Shape: White To Off-White

Molecular weight: 764.94

Ref: TR-D445950

Digitoxin

CAS: 71-63-6

Digitoxin is a cardiac glycoside, which is a type of compound extracted primarily from the leaves of the Digitalis purpurea plant, also known as the common foxglove. This natural source provides digitoxin with its potent pharmacological properties.

Formula: C₄₁H₆₄O₁₃

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 764.96 g/mol

Ref: 3D-OD09336

Digoxin EP Impurity A

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Molecular weight: 765

Ref: ST-EA-CP-D1200001

DigitoXin, USP

CAS: 71-63-6

Formula: C₄₁H₆₄O₁₃

Purity: 92%

Color and Shape: Solid

Molecular weight: 764.9391

Ref: IN-DA003PIK