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CAS 71138-97-1

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Hydroxypropyl methyl cellulose acetate succinate

Description:
Hydroxypropyl methyl cellulose acetate succinate (HPMCAS) is a semi-synthetic polymer derived from cellulose, characterized by its unique structure that incorporates hydroxypropyl, methyl, and acetate groups. This compound is primarily used as a film-forming agent and a polymeric excipient in pharmaceutical formulations, particularly for controlled drug release applications. HPMCAS is soluble in organic solvents and exhibits pH-dependent solubility, making it suitable for use in enteric coatings that protect drugs from gastric acid while allowing release in the more neutral pH of the intestines. Its properties include good thermal stability, biocompatibility, and the ability to form stable films, which contribute to its effectiveness in enhancing the solubility and bioavailability of poorly soluble drugs. Additionally, HPMCAS is recognized for its low toxicity and is generally regarded as safe for use in food and pharmaceutical products. Its versatility and functional characteristics make it a valuable ingredient in various formulations, including tablets, capsules, and other dosage forms.
Formula:C4H6O4·xC3H8O2·xC2H4O2·xCH4O·xUnspecified
InChI:InChI=1/C4H6O4.C3H8O2.C2H4O2.CH4O/c5-3(6)1-2-4(7)8;1-3(5)2-4;1-2(3)4;1-2/h1-2H2,(H,5,6)(H,7,8);3-5H,2H2,1H3;1H3,(H,3,4);2H,1H3
SMILES:C(CC(=O)O)C(=O)O.CC(CO)O.CC(=O)O.CO
Synonyms:
  • 2-Hydroxypropyl methyl cellulose acetate succinate
  • Affinisol 126G
  • Affinisol HPMCAS 912G
  • Aqoat
  • Aqoat AS-HF
  • Aqoat AS-L
  • Aqoat AS-LF
  • Aqoat AS-LG
  • Aqoat AS-LMP
  • Aqoat AS-M
  • See more synonyms
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