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CAS 71140-58-4

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Octanoylpolymyxin B

Description:
Octanoylpolymyxin B is a synthetic derivative of polymyxin B, an antibiotic that is primarily effective against Gram-negative bacteria. This compound is characterized by its amphiphilic nature, which allows it to interact with bacterial membranes, disrupting their integrity and leading to cell death. Octanoylpolymyxin B is notable for its enhanced lipophilicity due to the octanoyl group, which improves its ability to penetrate lipid membranes. It exhibits antibacterial activity, particularly against multidrug-resistant strains, making it a subject of interest in the development of new antimicrobial therapies. Additionally, its structure includes a cyclic peptide backbone and a fatty acid tail, contributing to its unique properties. The compound is typically used in research settings to study bacterial resistance mechanisms and may have potential applications in clinical settings, particularly in treating infections caused by resistant pathogens. However, like other polymyxins, it may also exhibit nephrotoxicity and neurotoxicity, necessitating careful consideration in therapeutic use.
Formula:C55H96N16O13
Synonyms:
  • Octanoylpolymyxin B
  • (-)-N2-(Octanoyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
  • Polymyxin B3
  • N2-(N2-Octanoyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
  • Polymyxin B1, 1-[(2S)-4-amino-2-[(1-oxooctyl)amino]butanoic acid]-
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