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CAS 71160-24-2

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Leukotriene B4

Description:
Leukotriene B4 (LTB4) is a potent lipid mediator involved in inflammatory responses and immune system regulation. It is a member of the leukotriene family, which are derived from arachidonic acid through the lipoxygenase pathway. LTB4 is characterized by its role as a chemotactic agent, attracting immune cells such as neutrophils to sites of inflammation. This compound is known for its ability to enhance vascular permeability and promote the release of other inflammatory mediators. LTB4 is a relatively unstable molecule, typically existing in a free form or bound to proteins in biological systems. Its structure includes a long hydrocarbon chain with multiple double bonds, contributing to its reactivity and biological activity. The substance is also implicated in various pathological conditions, including asthma, rheumatoid arthritis, and other inflammatory diseases. Due to its significant role in inflammation, LTB4 is a target for therapeutic interventions aimed at modulating immune responses.
Formula:C20H32O4
InChI:InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
InChI key:InChIKey=VNYSSYRCGWBHLG-AMOLWHMGSA-N
SMILES:C(=C\C=C\C=C\[C@@H](C/C=C\CCCCC)O)\[C@H](CCCC(O)=O)O
Synonyms:
  • (+)-Leukotriene B<sub>4</sub>
  • (5S,12R)-Leukotriene B<sub>4</sub>
  • (5S,6E,8Z,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5(S),12(R)-Dihydroxy-6-cis,8,10-trans,14-cis-eicosatetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxyicosa-6,8,10,14-Tetraenoic Acid
  • 5S,12R-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
  • 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-
  • See more synonyms
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