CAS 71204-89-2

Calcitroic acid

Description:

Calcitroic acid, with the CAS number 71204-89-2, is a chemical compound that serves as a metabolite of calcitriol, the active form of vitamin D. It is characterized by its role in the regulation of calcium and phosphate metabolism in the body. Structurally, calcitroic acid features a hydroxyl group and a carboxylic acid group, which contribute to its solubility in water and its biological activity. This compound is primarily involved in the feedback regulation of vitamin D levels, influencing the synthesis and degradation of calcitriol. Its presence in biological systems is significant for maintaining bone health and calcium homeostasis. Additionally, calcitroic acid may have implications in various physiological processes, including immune function and cell differentiation. While specific applications in medicine or industry may not be widely documented, understanding its biochemical pathways is crucial for comprehending vitamin D metabolism and its effects on human health.

Formula: C₂₃H₃₄O₄

InChI: InChI=1S/C23H34O4/c1-14(11-22(26)27)19-8-9-20-16(5-4-10-23(19,20)3)6-7-17-12-18(24)13-21(25)15(17)2/h6-7,14,18-21,24-25H,2,4-5,8-13H2,1,3H3,(H,26,27)/b16-6+,17-7-/t14-,18-,19-,20+,21+,23-/m1/s1

InChI key: InChIKey=MBLYZRMZFUWLOZ-ZTIKAOTBSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CC(O)=O)C)[H])[H]

Synonyms:

• (βR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-Dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-β,7a-dimethyl-1H-indene-1-propanoic acid
• 1α-Hydroxycalcioic acid
• 1H-Indene-1-propanoic acid, 4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-β,7a-dimethyl-, (βR,1R,3aS,4E,7aR)-
• 24-Nor-9,10-secochola-5,7,10(19)-trien-23-oic acid, 1,3-dihydroxy-, (1α,3β,5Z,7E)-
• Calcitroic acid

Calcitroic acid

CAS: 71204-89-2

Calcitroic acid is a vitamin D receptor (VDR) agonist that activates VDR-mediated transcription. It is the primary metabolite of 1,25-dihydroxyvitamin D3, showing the highest concentrations in the liver and mucosa of mice. The compound exhibits metabolic stability and extremely low toxicity.

Formula: C₂₃H₃₄O₄

Color and Shape: Solid

Molecular weight: 374.514

Ref: TM-TN8936

Calcitroic Acid

CAS: 71204-89-2

Formula: C₂₃H₃₄O₄

Molecular weight: 374.53

Ref: 4Z-V-1219

Calcitroic Acid

Controlled Product

CAS: 71204-89-2

Stability Light Sensitive
Applications Calcitroic Acid is a major metabolite of Calcitriol (C144500).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Esvelt, R.P. et al.: Arch. Biochem. Biophys., 206, 403 (1981); Onisko, B.L. et al.: Biochemistry, 19, 4124 (1980); Reddy, G.S. et al.: Biochemistry, 28, 1763 (1989);

Formula: C₂₃H₃₄O₄

Purity: >85%

Color and Shape: Neat

Molecular weight: 374.51

Ref: TR-C144550

Calcitroic acid

CAS: 71204-89-2

Calcitroic acid is a metabolite of vitamin D, which is derived from the enzymatic degradation of calcitriol, the hormonally active form of vitamin D3. This compound is found within biological systems as a result of the breakdown processes occurring in the liver and kidneys, orchestrated by specific enzyme activities that convert calcitriol into calcitroic acid. Its mode of action involves participation in the metabolic pathways that facilitate the regulation of calcium and phosphate homeostasis in the body, albeit as a less active form compared to its precursor, calcitriol.

Formula: C₂₃H₃₄O₄

Purity: Min. 95%

Molecular weight: 374.5 g/mol

Ref: 3D-WCA20489

Calcitroic Acid

CAS: 71204-89-2

Formula: C₂₃H₃₄O₄

Molecular weight: 374.52

Ref: ST-EA-CP-C49014