CAS 71324-48-6

2,2,2-trifluoro-N-[(7S)-1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl]acetamide

Description:

2,2,2-Trifluoro-N-[(7S)-1,2,3,9-tetramethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl]acetamide is a complex organic compound characterized by its unique molecular structure, which includes a trifluoroacetamide group and a tetrahydrobenzo[a]heptalene moiety. The presence of trifluoromethyl groups imparts significant polarity and can enhance the compound's biological activity, making it of interest in medicinal chemistry. The multiple methoxy groups contribute to its solubility and reactivity, while the ketone functionality suggests potential for further chemical transformations. This compound may exhibit specific pharmacological properties, potentially acting as an inhibitor or modulator in biological systems. Its stereochemistry, indicated by the (7S) configuration, is crucial for its interaction with biological targets. The compound's CAS number, 71324-48-6, allows for its identification in chemical databases, facilitating research and development in various applications, including pharmaceuticals and agrochemicals. Overall, this compound exemplifies the intricate relationship between molecular structure and biological activity in organic chemistry.

Formula: C₂₂H₂₂F₃NO₆

InChI: InChI=1/C22H22F3NO6/c1-29-16-10-13-12(6-8-15(16)27)18-11(5-7-14(13)26-21(28)22(23,24)25)9-17(30-2)19(31-3)20(18)32-4/h6,8-10,14H,5,7H2,1-4H3,(H,26,28)/t14-/m0/s1

SMILES: COc1cc2c(ccc1=O)c1c(CC[C@@H]2N=C(C(F)(F)F)O)cc(c(c1OC)OC)OC

Synonyms:

• acetamide, 2,2,2-trifluoro-N-[(7S)-5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl]-

N-Trifluoroacetyliso Deacetylcolchicine

Controlled Product

CAS: 71324-48-6

Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Formula: C₂₂H₂₂F₃NO₆

Color and Shape: Neat

Molecular weight: 453.41

Ref: TR-T788100