CAS 713516-99-5
:Ambrisentan
Description:
Ambrisentan is a selective endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and improving blood flow in the pulmonary arteries. Ambrisentan is characterized by its high affinity for the endothelin A receptor, which contributes to its therapeutic effects. The compound is typically administered orally and is known for its favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. It is also associated with potential side effects, such as peripheral edema, headache, and liver function abnormalities, necessitating regular monitoring of liver enzymes during treatment. Additionally, due to its teratogenic potential, it is contraindicated in pregnancy and requires effective contraception in women of childbearing age. Overall, Ambrisentan represents a significant advancement in the management of PAH, improving exercise capacity and quality of life for affected patients.
Formula:C22H22N2O4
InChI:InChI=1/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
SMILES:Cc1cc(C)nc(n1)O[C@H](C(=O)O)C(c1ccccc1)(c1ccccc1)OC
Synonyms:- Bsf 208075,(+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
- 2-(4,6-Dimethylpyrimidin-2-Yl)Oxy-3-Methoxy-3,3-Di(Phenyl)Propanoic Acid
- (As)-A-[(4,6-Dimethyl-2-Pyrimidinyl)Oxy]--Methoxy--Phenylbenzenepropanoic Acid
- Bsf 208075
- Lu 208075
- (2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 2 products.
