CAS 714272-27-2

Plinabulin

Description:

Plinabulin is a small molecule with the chemical formula C19H22N2O2, primarily known for its role as an immunomodulatory agent and its potential applications in oncology. It functions by targeting the microtubule dynamics within cells, which can lead to the inhibition of tumor growth and enhancement of immune responses. Plinabulin has been investigated for its ability to mitigate chemotherapy-induced neutropenia, thereby improving the safety and efficacy of cancer treatments. The compound exhibits a unique mechanism of action that distinguishes it from traditional chemotherapeutic agents, making it a subject of interest in cancer research. Additionally, Plinabulin has shown promise in preclinical and clinical studies, demonstrating a favorable safety profile. Its pharmacokinetics and bioavailability are also key areas of study, as they influence its therapeutic potential. Overall, Plinabulin represents a novel approach in cancer therapy, combining immunomodulation with direct anti-tumor effects, and continues to be evaluated in clinical settings for its efficacy and safety in various cancer types.

Formula: C₁₉H₂₀N₄O₂

InChI: InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9-,15-10-

InChI key: InChIKey=UNRCMCRRFYFGFX-TYPNBTCFSA-N

SMILES: C(\C1=C(C(C)(C)C)N=CN1)=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2

Synonyms:

• (3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione
• (3Z,6Z)-3-[[5-(1,1-Dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-2,5-piperazinedione
• 2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-, (3Z,6Z)-
• Bpi 2358
• Npi 2358
• Plinabulin

Plinabulin(NPI-2358)

CAS: 714272-27-2

Formula: C₁₉H₂₀N₄O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 336.3877

Ref: IN-DA00FEQH

Plinabulin

CAS: 714272-27-2

Plinabulin

Purity: ≥90%

Molecular weight: 336.39g/mol

Ref: 54-BUP05667

Plinabulin

CAS: 714272-27-2

Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).

Formula: C₁₉H₂₀N₄O₂

Purity: 98.69% - >99.99%

Color and Shape: Solid

Molecular weight: 336.39

Ref: TM-T2511