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CAS 71439-68-4

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Bisantrene hydrochloride

Description:
Bisantrene hydrochloride is a synthetic anthracene derivative and an antineoplastic agent primarily investigated for its potential use in cancer therapy. It exhibits a unique mechanism of action, primarily functioning as a DNA intercalator, which disrupts the replication and transcription processes in cancer cells. This compound is characterized by its ability to form stable complexes with DNA, leading to cytotoxic effects. Bisantrene hydrochloride is typically administered in a hydrochloride salt form, enhancing its solubility and stability in aqueous solutions. The substance is known for its moderate lipophilicity, which influences its distribution and bioavailability in biological systems. Additionally, it has been studied for its potential to overcome drug resistance in certain cancer types. However, like many chemotherapeutic agents, it may also exhibit side effects, including myelosuppression and gastrointestinal disturbances. Research continues to explore its efficacy and safety profile in various cancer treatments, making it a compound of interest in oncology.
Formula:C22H22N8·2ClH
InChI:InChI=1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H
InChI key:InChIKey=KINULKKPVJYRON-UHFFFAOYSA-N
SMILES:C(=NNC=1NCCN1)C=2C3=C(C(C=NNC=4NCCN4)=C5C2C=CC=C5)C=CC=C3.Cl
Synonyms:
  • 2,2'-{Anthracene-9,10-diylbis[(Z)methylylidene(2Z)hydrazin-1-yl-2-ylidene]}bis-4,5-dihydro-1H-imidazole dihydrochloride
  • 2,2'-{anthracene-9,10-diylbis[(E)methylylidene(2E)hydrazin-1-yl-2-ylidene]}bis-4,5-dihydro-1H-imidazole dihydrochloride
  • 71439-68-4
  • 9,10-Anthracenedicarboxaldehyde, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], hydrochloride (1:2)
  • 9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride
  • Adah
  • Adca
  • Bisantrene dihydrochloride
  • Cl 216942
  • NSC 337766
  • See more synonyms
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