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CAS 71548-19-1

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6-trans-12-epi-LTB4

Description:
6-trans-12-epi-LTB4, with the CAS number 71548-19-1, is a bioactive lipid belonging to the leukotriene family, which are eicosanoid compounds derived from arachidonic acid. This substance is characterized by its role as a potent inflammatory mediator, influencing various physiological processes such as immune response, vascular permeability, and smooth muscle contraction. Structurally, it features a unique configuration that distinguishes it from other leukotrienes, particularly in its trans double bond and specific stereochemistry at the 12-position. The compound is known to interact with leukotriene receptors, contributing to its biological effects, which include chemotaxis of immune cells and modulation of inflammatory responses. Due to its involvement in various pathophysiological conditions, including asthma and other inflammatory diseases, 6-trans-12-epi-LTB4 is of significant interest in pharmacological research. Its stability, solubility, and reactivity are influenced by its lipid nature, making it a subject of study in both biochemistry and medicinal chemistry.
Formula:C20H32O4
InChI:InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19+/m0/s1
InChI key:InChIKey=VNYSSYRCGWBHLG-CTOJTRLNSA-N
SMILES:C(=C/C=C/C=C/[C@H](C/C=C\CCCCC)O)\[C@H](CCCC(O)=O)O
Synonyms:
  • (5S,6E,8E,10E,12S,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
  • 12-epi-Δ<sup>6</sup>-trans-Leukotriene B<sub>4</sub>
  • 5(S),12(S)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoic acid
  • 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6E,8E,10E,12S,14Z)-
  • 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, [S-[R*,R*-(E,E,E,Z)]]-
  • 6-trans-12-epi-LTB<sub>4</sub>
  • 6-trans-12-epi-Leukotriene B<sub>4</sub>
  • 71548-19-1
  • Δ<sup>6</sup>-trans-12-Epileukotriene B<sub>4</sub>
  • Δ<sup>6</sup>-trans-12-epi-LTB<sub>4</sub>
  • Δ6-trans-12-Epileukotriene B4
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