CAS 716-61-0

Chloramphenicol base

Description:

Chloramphenicol base, with the CAS number 716-61-0, is a broad-spectrum antibiotic that was originally derived from the bacterium Streptomyces venezuelae. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, effectively blocking peptide bond formation. This compound is a white to pale yellow crystalline powder that is soluble in water and organic solvents such as ethanol and acetone. Chloramphenicol exhibits a relatively low molecular weight and has a unique nitrobenzene structure, which contributes to its pharmacological properties. While it is effective against a wide range of gram-positive and gram-negative bacteria, its use has declined due to potential side effects, including aplastic anemia and gray baby syndrome in newborns. Chloramphenicol is still utilized in specific clinical situations, particularly for treating typhoid fever and certain serious infections when other antibiotics are ineffective. Its use is regulated in many countries due to safety concerns, emphasizing the importance of careful monitoring when prescribed.

Formula: C₉H₁₂N₂O₄

InChI: InChI=1/C9H12N2O4/c10-8(5-12)9(13)6-1-3-7(4-2-6)11(14)15/h1-4,8-9,12-13H,5,10H2/p+1/t8-,9-/m1/s1

InChI key: InChIKey=OCYJXSUPZMNXEN-RKDXNWHRSA-N

SMILES: [C@@H]([C@@H](CO)N)(O)C1=CC=C(N(=O)=O)C=C1

Synonyms:

• (-)-threo-1-(p-Nitrophenyl)-2-amino-1,3-propanediol
• (1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol
• (1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-aminium
• (1R,2R)-2-Amino-1-(4-Nitrophenol)Propane-1,3-Diol
• (1R,2R)-2-Amino-1-(4-Nitrophenyl)Propane-1,3-Diol
• (1R,2R)-threo-(-)-1-(4-Nitrophenyl)-2-amino-1,3-propanediol
• 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-
• 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, [R-(R*,R*)]-
• 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, <span class="text-smallcaps">D</span>-threo-(-)-
• <span class="text-smallcaps">D</span>-(-)-threo-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-(-)-trans-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-1-(p-Nitrophenyl)-2-aminopropane-1,3-diol
• <span class="text-smallcaps">D</span>-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
• <span class="text-smallcaps">D</span>-threo-(1R,2R)-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• Amino-1-(4-nitrophenyl)propane-1,3-diol, (1R,2R)-2-
• Aminonitrophenolpropanediol
• Chloramphenicol D base
• Chloramphenicol base
• Chloramphenicol-Water Soluble
• D(-)Threo-1-(4-Nitro-Phenyl)-2-Amino-1,3-Propanediol
• D-(-)-Threo-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol
• D-Threo-(-)-2-Amino-1-(P-Nitrophenyl)-1,3-Propanediol
• L-Base
• Levoamine
• 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-
• (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol,96%
• Chloramphenicol base, D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• (1R,2R)-1-(4-Nitrophenyl)-2-aminopropane-1,3-diol
• D
• (1R,2R)-2-AMino-1-(4-nitrophenyl)propane-1,3-diol, 96% 5GR
• chloramphenicolbase
• (1R,2R)-(-)-2-AMINO-1-NITROPHENYL)-1,3-PROPANEDIOL
• (1R,2R)-()-2-Amino-1-(4-nitrophenyl)-1,3-propanediol,D-()-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, Chloramphenicol base
• -2-Amino-1-(4-nitrophenyl)-1,3-propanediol
• [1R,2R,(-)]-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol
• (1R,2R)-(-)-2-AMINO-1-ITROPHENYL)-1,3-PR OPANEDIOL,99%
• D-THREO-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANE
• L-BASE (AMINODIOL)
• (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol hydrochloride
• D(-)Threo-1-(4-nitro-phenyl)-2
• -(-)-
• 2-amino-1-(p-nitrophenyl)-3-propanediod-threo-(-)-
• CHLORAMPHENICOL BASE CRYSTALLINE
• Chloromycin base
• (R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
• (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol, 96%, 96%
• (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol 99%
• threo

2-amino-1-(4-nitrophenyl)propane-1,3-diol

CAS: 716-61-0

2-amino-1-(4-nitrophenyl)propane-1,3-diol

Color and Shape: White Powder

Ref: 47-417

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 212.2026

Ref: IN-DA005QRY

(1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol

CAS: 716-61-0

(1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol

Purity: 98%

Molecular weight: 212.2g/mol

Ref: 54-OR1029092

(1R,2R)-(-)-2-Amino-1-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white or pale yellow-orange powder or crystals

Molecular weight: 212.21

Ref: 7W-GK6757

Chloramphenicol EP Impurity A

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Color and Shape: Off-White Solid

Molecular weight: 212.21

Ref: 4Z-C-10104

Chloramphenicol EP Impurity A

Controlled Product

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Color and Shape: Neat

Molecular weight: 212.20

Ref: 86-MM0516.01

D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purity: >98.0%(T)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 212.21

Ref: 3B-A1017

Chloramphenicol EP Impurity A

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Molecular weight: 212.21

Ref: ST-EA-CP-C161001

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Applications D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuelae.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mehta, J., et al.: J. Biotechnol., 155, 361 (2011); Samsonova, J.V., et al.: Anal. Lett., 43, 133 (2010); Cravedi, J. P., et al.: Chem. Res. Toxciol., 8, 642 (1995); Wal, J.M., et al.: Antimicrob. Agent. Chemother., 24, 89 (1983);

Formula: C₉H₁₂N₂O₄

Color and Shape: Off-White To Light Yellow

Molecular weight: 212.20

Ref: TR-A622680

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Purity: 98%

Molecular weight: 212.21

Ref: 10-F790946

D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol

Controlled Product

CAS: 716-61-0

Applications D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol is an intermediate in the synthesis of Chloramphenicol-d5 (C325033), the labeled analogue of Chloramphenicol (C325030), which has a broad spectrum of activity against Gram-positive and gram-negative bacteria. It is also antibacterial, and antirickettsial.
References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

Formula: C₉D₄H₈N₂O₄

Color and Shape: Neat

Molecular weight: 216.227

Ref: TR-A622682