CAS 71652-82-9

6-trans-Leukotriene B4

Description:

6-trans-Leukotriene B4 is a bioactive lipid mediator belonging to the leukotriene family, which are derived from arachidonic acid through the lipoxygenase pathway. This compound is characterized by its role in inflammatory responses and immune system regulation. It is a potent chemotactic agent, attracting immune cells such as neutrophils to sites of inflammation. Structurally, 6-trans-Leukotriene B4 features a triene system, which is crucial for its biological activity, and it is known for its high affinity for specific leukotriene receptors. The substance is typically produced in response to various stimuli, including allergens and pathogens, and plays a significant role in conditions such as asthma, allergic reactions, and other inflammatory diseases. Its synthesis and metabolism are tightly regulated, and it can be measured in biological fluids as a marker of inflammation. Due to its potent effects, 6-trans-Leukotriene B4 is a target for therapeutic interventions aimed at modulating inflammatory processes.

Formula: C₂₀H₃₂O₄

InChI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11+/t18-,19-/m1/s1

InChI key: InChIKey=VNYSSYRCGWBHLG-UKNWISKWSA-N

SMILES: C(=C/C=C/C=C/[C@@H](C/C=C\CCCCC)O)\[C@H](CCCC(O)=O)O

Synonyms:

• (5S,6E,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
• (5S,6E,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
• (6E,5S,12R)-Leukotriene B₄
• 5(S),12(R)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoic acid
• 5S,12R-Dihydroxy-6E,8E,10E,14Z-eicosatetraenoic acid
• 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6E,8E,10E,12R,14Z)-
• 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, [S-[R*,S*-(E,E,E,Z)]]-
• 6-trans-LTB₄
• 6-trans-Leukotriene B₄
• Δ⁶-trans-LTB₄
• Δ⁶-trans-Leukotriene B₄