CAS 71675-92-8

S-(-)-Amisulpride

Description:

S-(-)-Amisulpride is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and depressive disorders. It is a selective antagonist of dopamine D2 and D3 receptors, which contributes to its therapeutic effects. The compound is characterized by its chiral nature, with the "S" designation indicating its specific stereochemistry, which is crucial for its pharmacological activity. S-(-)-Amisulpride is known for its relatively low affinity for serotonin receptors, distinguishing it from many other antipsychotics. It is typically administered orally and has a favorable pharmacokinetic profile, including good oral bioavailability and a moderate half-life. The substance is soluble in water and exhibits a moderate to high degree of lipophilicity, influencing its distribution in the body. Side effects may include extrapyramidal symptoms, but these are generally less pronounced compared to typical antipsychotics. Overall, S-(-)-Amisulpride represents a significant option in the management of certain psychiatric conditions, with a unique mechanism of action that underscores its clinical utility.

Formula: C₁₇H₂₇N₃O₄S

InChI: InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)/t12-/m0/s1

InChI key: InChIKey=NTJOBXMMWNYJFB-LBPRGKRZSA-N

SMILES: C(NC[C@H]1N(CC)CCC1)(=O)C2=C(OC)C=C(N)C(S(CC)(=O)=O)=C2

Synonyms:

• 4-Amino-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
• Benzamide,4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-, (S)-
• Esamisulpride
• S-(-)-Amisulpride
• Benzamide, 4-amino-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-(ethylsulfonyl)-2-methoxy-

(S)-Amisulpride

CAS: 71675-92-8

(S)-Amisulpride

Purity: ≥98%

Molecular weight: 369.48g/mol

Ref: 54-BUP07858

(S)-Amisulpride

CAS: 71675-92-8

(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist.

Formula: C₁₇H₂₇N₃O₄S

Purity: 98.38%

Color and Shape: Solid

Molecular weight: 369.48

Ref: TM-T26375

S-Amisulpride

Controlled Product

CAS: 71675-92-8

Applications S-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). S-Amisulpride has been shown to produce a maximal increase in prolactin level similar to that of the racemic form of Amisulpride.
References Protais, P., et al.: Neuropharmacol., 24, 861 (1985); Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997); Marchese, G., et. al.: Eur. J. Pharmacol., 448, 263 (2002)

Formula: C₁₇H₂₇N₃O₄S

Color and Shape: Neat

Molecular weight: 369.48

Ref: TR-A633260

S-Amisulpride

Controlled Product

CAS: 71675-92-8

S-Amisulpride is a benzamide antipsychotic drug that is an atypical antipsychotic. It has been shown to be effective in the treatment of schizophrenia, schizoaffective disorder, and bipolar disorder. Amisulpride was first synthesized by a French company called Laboratoires Servier and it was approved for sale in France in 1988. The drug is available as tablets for oral administration. The clinical effects of amisulpride are due to its ability to block dopamine receptors and serotonin receptors, which are neurotransmitters that play a role in the regulation of mood. Amisulpride also has stereoselective properties as it is active as an antipsychotic only when administered in the S-enantiomer form.

Formula: C₁₇H₂₇N₃O₄S

Purity: Min. 95%

Molecular weight: 369.5 g/mol

Ref: 3D-WCA67592

S-Amisulpride

CAS: 71675-92-8

Formula: C₁₇H₂₇N₃O₄S

Molecular weight: 369.48

Ref: ST-EA-CP-A16015