CAS 7177-50-6
:Sodium nafcillin monohydrate
Description:
Sodium nafcillin monohydrate is a semisynthetic penicillin antibiotic, primarily used to treat infections caused by penicillinase-producing staphylococci. It is characterized by its ability to resist degradation by certain beta-lactamases, making it effective against specific bacterial strains. The compound appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration via injection. Its molecular structure includes a beta-lactam ring, a thiazolidine ring, and a sodium ion, contributing to its antibacterial properties. Sodium nafcillin monohydrate is typically administered intravenously or intramuscularly, and its pharmacokinetics involve rapid distribution in body tissues, with a relatively short half-life. Common side effects may include allergic reactions, gastrointestinal disturbances, and potential nephrotoxicity. As with other antibiotics, it is essential to use sodium nafcillin monohydrate judiciously to prevent the development of antibiotic resistance. Overall, it remains a critical option in the treatment of certain bacterial infections, particularly those caused by resistant strains.
Formula:C21H23N2NaO6S
InChI:InChI=1/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1
InChI key:InChIKey=RKBDQTFFBRQMPN-KMFBOIRUSA-N
SMILES:C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C4=C(C=CC3OCC)C=CC=C4)C2=O)(SC1(C)C)[H].[Na].O
Synonyms:- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S-(2alpha,5alpha,6beta))
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
- Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate monohydrate
- Nafcil
- Nafcillin natrium-1-wasser
- Nafcillin sodium salt monohydrate
- Sodium 6-(2-ethoxy-1-naphthamido)penicillanate monohydrate
- Sodium nafcillin monohydrate
- Unii-49G3001Bck
- Wy 3277
- sodium (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
- Nafcillin monohydrate sodium salt
- NAFCILLINSODIUMSTERILE
- Sodium (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
- nafcillin sodium
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 11 products.
Nafcillin Sodium
CAS:Penicillins and their derivatives with a penicillanic acid structure and salts thereof, nesoiFormula:C21H21N2NaO5S·H2OColor and Shape:White Light Yellow Crystalline PowderMolecular weight:454.11745(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium hydrate
CAS:Formula:C21H23N2NaO6SPurity:98%Color and Shape:SolidMolecular weight:454.4719Nafcillin sodium monohydrate
CAS:Nafcillin sodium monohydrate (CL 8491) is a semi-synthetic naphthalene, nafcillin inhibits bacterial wall synthesis by a mechanism similar to penicillin.
Formula:C21H21N2O5SNa·H2OPurity:96.62%Color and Shape:White PowderMolecular weight:454.47Nafcillin sodium salt monohydrate
CAS:Nafcillin sodium salt monohydratePurity:98%(Contain 2-3% ethyl acetate)Molecular weight:454.47g/molNafcillin sodium monohydrate 100 µg/mL in Acetonitrile
CAS:Formula:C21H21N2O5S·Na·H2OColor and Shape:Single SolutionMolecular weight:454.47Nafcillin sodium salt monohydrate
CAS:Formula:C21H21N2O5SNa·H2OPurity:≥ 98.5% (anhydrous basis)Color and Shape:White to yellow crystalline powder or crystalsMolecular weight:454.47Sodium Nafcillin Monohydrate
CAS:Applications Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria.
References Taboada, P. et al.: Langmuir. 16, 3175 (2000);Formula:C21H21N2O5S·Na·H2OColor and Shape:Off-WhiteMolecular weight:454.47Nafcilllin sodium monohydrate
CAS:Nafcillin sodium monohydrate is a beta-lactam antibiotic, which is derived from the penicillin class of antimicrobials. It is specifically a semi-synthetic penicillin and is commonly sourced through chemical synthesis to enhance its stability and spectrum of activity. Nafcillin primarily exerts its bactericidal effects by inhibiting bacterial cell wall synthesis. It achieves this through its strong affinity for penicillin-binding proteins (PBPs), which are essential for maintaining the bacterial cell wall structure. By disrupting the formation of peptidoglycan cross-links, nafcillin effectively weakens the bacterial cell wall, leading to cell lysis and death, especially in gram-positive bacteria such as Staphylococcus aureus, including methicillin-sensitive strains (MSSA).Formula:C21H21N2O5SNa·H2OPurity:Min. 95%Color and Shape:White to off-white solid.Molecular weight:454.47 g/mol
![(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0062G3.jpg&w=3840&q=75)
