CAS 717906-29-1

PF431396

Description:

PF431396 is a small molecule inhibitor primarily known for its role in targeting specific kinases, particularly the focal adhesion kinase (FAK). It is characterized by its ability to interfere with cellular signaling pathways that are crucial for processes such as cell adhesion, migration, and survival, making it of interest in cancer research and potential therapeutic applications. The compound is typically presented as a white to off-white solid and is soluble in organic solvents, which facilitates its use in various biochemical assays. PF431396 has been studied for its effects on tumor growth and metastasis, showing promise in preclinical models. Its mechanism of action involves the inhibition of FAK phosphorylation, which can lead to reduced tumor cell proliferation and enhanced apoptosis. As with many small molecule inhibitors, the specificity and selectivity of PF431396 are critical for minimizing off-target effects and maximizing therapeutic efficacy. Overall, PF431396 represents a valuable tool in the exploration of targeted cancer therapies.

Formula: C₂₂H₂₁F₃N₆O₃S

InChI: InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30)

SMILES: CN(c1ccccc1CN=c1c(cnc(Nc2ccc3c(c2)CC(=O)N3)[nH]1)C(F)(F)F)S(=O)(=O)C

Synonyms:

• N-Methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]phenyl}methanesulfonamide

N-Methyl-N-[2-[[2-[(2-Oxo-2,3-Dihydro-1H-Indole-5-Yl)Amino]-5-Trifluoromethylpyrimidin-4-Yl]Amino]Methyl]Phenyl] Methanesulfonamide

CAS: 717906-29-1

N-Methyl-N-[2-[[2-[(2-Oxo-2,3-Dihydro-1H-Indole-5-Yl)Amino]-5-Trifluoromethylpyrimidin-4-Yl]Amino]Methyl]Phenyl] Methanesulfonamide

Purity: 99%

Molecular weight: 506.5g/mol

Ref: 54-PC108578

PF-431396 hydrate

CAS: 717906-29-1

Formula: C₂₂H₂₁F₃N₆O₃S·xH₂O

Molecular weight: 506.50 (anhydrous)

Ref: 7W-GL7199

PF-431396

CAS: 717906-29-1

PF-431396

Purity: ≥98%

Molecular weight: 506.5g/mol

Ref: 54-BUP10467

PF-431396

CAS: 717906-29-1

PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).

Formula: C₂₂H₂₁F₃N₆O₃S

Purity: 98.83% - 99.82%

Color and Shape: Solid

Molecular weight: 506.5

Ref: TM-T2314

PF 431396

Controlled Product

CAS: 717906-29-1

Applications PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Han, et al.: J. Biol. Chem., 284 13193 (2009), Allen, et al.: J. Med. Chem., 53 4332 (2010),

Formula: C₂₂H₂₁F₃N₆O₃S

Color and Shape: Neat

Molecular weight: 506.5

Ref: TR-P218290