CAS 71800-36-7

lys-des-arg9-bradykinin

Description:

Lys-des-Arg9-bradykinin, also known as a bradykinin analog, is a peptide that plays a significant role in various physiological processes, particularly in the regulation of blood pressure and inflammation. It is derived from bradykinin, a potent vasodilator, by the removal of the C-terminal arginine residue. This modification alters its biological activity and receptor binding properties. The peptide consists of a sequence of amino acids that contribute to its function, primarily interacting with the B2 bradykinin receptor. Characteristically, it exhibits a high degree of water solubility due to its peptide nature, and it is typically stable under physiological conditions. Its pharmacological effects include promoting vasodilation, increasing vascular permeability, and modulating pain responses. Research has indicated that lys-des-Arg9-bradykinin may have therapeutic potential in conditions such as cardiovascular diseases and pain management. However, its use in clinical settings requires further investigation to fully understand its efficacy and safety profile.

Formula: C₅₀H₇₃N₁₃O₁₁

InChI: InChI=1/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1

SMILES: c1ccc(cc1)C[C@@H](C(=N[C@@H](CO)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=O)O)O)O)N=C(CN=C([C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N=C([C@H](CCCCN)N)O)O)O

Synonyms:

• Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

Lys-(Des-Arg⁹)-Bradykinin

CAS: 71800-36-7

Bachem ID: 4026993.

Formula: C₅₀H₇₃N₁₃O₁₁

Purity: 98.6%

Color and Shape: White Lyophilisate

Molecular weight: 1032.21

Ref: 01-4026993

Lys-[Des-Arg9]Bradykinin

CAS: 71800-36-7

Selective bradykinin B1 agonist with Ki 0.12 nM; inactive at B2 (>30,000 nM). Lowers blood pressure, more potent than Des-Arg9-Bradykinin.

Formula: C₅₀H₇₃N₁₃O₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 1032.21

Ref: TM-TP1918

Des-Arg10-Kallidin

Controlled Product

CAS: 71800-36-7

Kallidin is a peptide that is found in the venom of the Brazilian pit viper (Bothrops jararaca). It has been shown to activate ion channels and receptors. Des-Arg10-Kallidin is a research tool that can be used in cell biology, pharmacology, and life science research. This peptide binds to antibodies and creates an ion channel when it binds to a receptor. Kallidin also inhibits protein interactions by binding to the active site of proteases such as thrombin, trypsin, and cathepsin B. The high purity of this peptide makes it ideal for use in pharmaceuticals.

Formula: C₅₀H₇₃N₁₃O₁₁

Purity: Min. 95%

Molecular weight: 1,032.2 g/mol

Ref: 3D-PBK-4303-V

Lys-(Des-Arg9)-Bradykinin trifluoroacetate salt

CAS: 71800-36-7

Lys-(Des-Arg9)-Bradykinin trifluoroacetate salt H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH trifluoroacetate salt (KBP) is a peptide that increases blood pressure by binding to the b2 receptor. This drug has been shown to be a potent pressor in animals and humans, with a concentration response curve similar to that of epinephrine. KBP binds to the extracellular domain of the b2 receptor, which activates this receptor and promotes the release of growth factors, such as epidermal growth factor (EGF). The high affinity of KBP for the b2 receptor is thought to be due to its ability to sequester EGF.

Formula: C₅₀H₇₃N₁₃O₁₁

Purity: Min. 95%

Molecular weight: 1,032.2 g/mol

Ref: 3D-FL108890