CAS 718612-49-8

SN-38-D3

Description:

SN-38-D3, with the CAS number 718612-49-8, is a derivative of SN-38, which is an active metabolite of the chemotherapeutic agent irinotecan. This compound is primarily characterized by its role in cancer treatment, particularly in the management of colorectal cancer. SN-38-D3 is notable for its enhanced solubility and stability compared to its parent compound, which can improve its therapeutic efficacy and reduce side effects. The chemical structure of SN-38-D3 includes a modified hydroxyl group, contributing to its pharmacological properties. It exhibits potent topoisomerase I inhibitory activity, which is crucial for its mechanism of action, as it interferes with DNA replication and transcription in cancer cells. Additionally, SN-38-D3 is subject to metabolic processes that can influence its bioavailability and overall effectiveness. Research into this compound continues to explore its potential benefits in combination therapies and its pharmacokinetic profile, aiming to optimize cancer treatment regimens.

Formula: C₂₂H₂₀N₂O₅

Synonyms:

• (4S)-4-(Ethyl-d3)-11-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-Ethyl-11-(ethyl-d3)-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 7-Ethyl-10-hydroxycamptothecin-d3
• 10-Hydroxy-7-ethylcamptothecin-d3
• SN-38-D5
• SN-38-D3
• SN 38-d3 Lactone

SN-38-d3

Controlled Product

CAS: 718612-49-8

Applications Labelled SN-38, a metabolite of Irinotecan, a DNA topoisomerase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000), Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2003), Ashley, G., et al.: J. Antibiot., 57, 224 (2004),

Formula: C₂₂₂H₃H₁₇N₂O₅

Color and Shape: Light Yellow

Molecular weight: 395.42

Ref: TR-S589952

SN-38-d3

CAS: 718612-49-8

SN-38-d3 is a deuterated form of SN-38. As the active metabolite of the topoisomerase I (TopoisomeraseI) inhibitor irinotecan, SN-38 (NK012) notably inhibits the synthesis of DNA and RNA, with IC50 values of 0.077 and 1.3 μM, respectively.

Formula: C₂₂H₂₀N₂O₅

Color and Shape: Solid

Molecular weight: 395.42

Ref: TM-T89645

Sn-38-d3

CAS: 718612-49-8

Sn-38-d3 is an isotope of tin. It is a competitive inhibitor and an activator of ligand-gated ion channels, such as nicotinic acetylcholine receptors. It also binds to the muscarinic acetylcholine receptor and can be used to identify other ligands that bind to this receptor. Sn-38-d3 has shown no significant inhibitory effects on the functions of peptide neurotransmitters or purinergic receptors.

Formula: C₂₂H₂₀N₂O₅

Purity: Min. 95%

Molecular weight: 395.4 g/mol

Ref: 3D-TDB61249