CAS 7187-66-8

Trimethaphan

Description:

Trimethaphan, with the CAS number 7187-66-8, is a synthetic compound classified as a ganglionic blocker. It is primarily used in medical settings for its ability to induce hypotension during surgical procedures or to manage hypertensive emergencies. The substance acts by inhibiting the transmission of nerve impulses in the autonomic nervous system, particularly at the autonomic ganglia, leading to vasodilation and a decrease in blood pressure. Trimethaphan is typically administered intravenously due to its rapid onset of action. It is a quaternary ammonium compound, which contributes to its solubility in water and limits its ability to cross the blood-brain barrier. Side effects may include hypotension, tachycardia, and gastrointestinal disturbances, reflecting its systemic effects on the autonomic nervous system. Due to its specific action and potential side effects, trimethaphan is used under careful medical supervision. Its use has declined with the advent of newer antihypertensive agents, but it remains a relevant compound in certain clinical scenarios.

Formula: C₂₂H₂₅N₂OS

InChI: InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

InChI key: InChIKey=CHQOEHPMXSHGCL-UHFFFAOYSA-N

SMILES: C(N1C2C(N(CC3=CC=CC=C3)C1=O)C[S+]4C2CCC4)C5=CC=CC=C5

Synonyms:

• Trimetaphan
• Thieno[1′,2′:1,2]thieno[3,4-d]imidazol-5-ium, 1,3-dibenzyldecahydro-2-oxo-
• Trimethaphan
• Thieno[1′,2′:1,2]thieno[3,4-d]imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)-
• Decahydro-2-oxo-1,3-bis(phenylmethyl)thieno[1′,2′:1,2]thieno[3,4-d]imidazol-5-ium

Trimetaphan camsilate

CAS: 7187-66-8

Trimetaphan camsilate, short-acting IV drug, blocks cholinergic transmission at autonomic ganglia, affecting both sympathetic and parasympathetic systems.

Formula: C₂₂H₂₅N₂OS

Color and Shape: Solid

Molecular weight: 365.51

Ref: TM-T68811