CAS 71939-50-9

Dihydroartemisinin

Description:

Dihydroartemisinin is a semi-synthetic derivative of artemisinin, which is derived from the sweet wormwood plant, Artemisia annua. It is primarily known for its potent antimalarial properties and is widely used in the treatment of malaria, particularly in combination therapies to enhance efficacy and reduce resistance. Dihydroartemisinin is characterized by its molecular formula, which typically includes carbon, hydrogen, and oxygen atoms, reflecting its organic nature. The compound is a white to off-white crystalline powder that is soluble in organic solvents but has limited solubility in water. Its mechanism of action involves the generation of reactive oxygen species upon activation in the presence of heme, leading to the destruction of the malaria parasite. Dihydroartemisinin is generally well-tolerated, with a favorable safety profile, although some side effects may occur. Its rapid onset of action and short half-life make it an effective choice in acute malaria treatment, often administered in combination with other antimalarial drugs to improve therapeutic outcomes.

Formula: C₁₅H₂₄O₅

InChI: InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1

InChI key: InChIKey=BJDCWCLMFKKGEE-ISOSDAIHSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1O)[H])[H]

Synonyms:

• (3R,5aS,6R,8aS,9R,10R,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
• (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
• (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
• (3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
• (3R,5aS,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
• (5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
• (5aS,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10α,12β,12aR*)]-
• Alaxin
• Artemisinin deriv. DHA
• Artenimol
• Cid 3000518
• Cotecxin
• Cotexin
• Dhqhs 1
• Dhqhs 2
• Di-hydro artemisinin
• Dihydroartemisinin
• Dihydroartemisinine
• Dihydroqinghaosu
• Dynamax
• Hc 101C
• Salaxin
• Santecxin
• β-Dihydroartemisinin

Dihydroartemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 284.35

Ref: 3B-D3793

Dihydroartemisinin

CAS: 71939-50-9

Dihydroartemisinin analytical standard

Formula: C₁₅H₂₄O₅

Color and Shape: Powder

Molecular weight: 284.35

Ref: 11-3817

ARTENIMOL RS

CAS: 71939-50-9

ARTENIMOL RS

Ref: 41-ICRS1410

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 284.3481

Ref: IN-DA003PIV

Dihydroartemisinin

CAS: 71939-50-9

Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!

Formula: C₁₅H₂₄O₅

Purity: 98% - 99.41%

Color and Shape: White Solid

Molecular weight: 284.35

Ref: TM-T0607

Dihydroartemisinin

CAS: 71939-50-9

Dihydroartemisinin

Purity: ≥98%

Molecular weight: 284.35g/mol

Ref: 54-BUP00192

Dihydroartemisinin,mixture of α and β isomers

CAS: 71939-50-9

Dihydroartemisinin,mixture of α and β isomers

Purity: 98%

Molecular weight: 284.35g/mol

Ref: 54-OR1029059

Dihydroartemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Purity: 95%~99%

Molecular weight: 284.352

Ref: BP-BP0491

Dihydroartemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Molecular weight: 284.36

Ref: 4Z-A-3013

Dihydroartemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 284.35

Ref: 7W-GY7819

Artemether USP Related Compound A

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Molecular weight: 284.35

Ref: ST-EA-CP-A119004

Dihydroartemisinin

CAS: 71939-50-9

Dihydroartemisinin is an antimalarial agent, which is a semi-synthetic derivative of artemisinin. Artemisinin is a naturally occurring sesquiterpene lactone derived from the sweet wormwood plant, Artemisia annua. The mode of action of dihydroartemisinin involves the generation of free radicals within the parasite's cells. This process occurs when the endoperoxide bridge in its chemical structure reacts with iron, leading to oxidative damage and subsequent parasite death.

Formula: C₁₅H₂₄O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 284.35 g/mol

Ref: 3D-FD11674

Dihydro Artemisinin-13C,d4

Controlled Product

CAS: 71939-50-9

Applications The labelled analogue of the main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite.
References de Vries, P., et al.: Drugs, 52, 818 (1996), Kamolrat, S., et al.: Antimicrob. Agents Chemother., 47, 3795 (2003), Mithwani, S., et al.: Br. J. Clin. Pharmacol., 57, 146 (2004),

Formula: CC₁₄D₄H₂₀O₅

Color and Shape: Neat

Molecular weight: 289.365

Ref: TR-D448363

Dihydroartemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Molecular weight: 284.35

Ref: ST-EA-CP-D51000

Artesunate IP Impurity A

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Molecular weight: 284.35

Ref: ST-EA-CP-A93011

Dihydro Artemisinin

CAS: 71939-50-9

Formula: C₁₅H₂₄O₅

Color and Shape: White to Off-White Solid

Molecular weight: 284.35

Ref: TR-D448360

Dihydro Artemisinin-13C,d5

Controlled Product

CAS: 71939-50-9

Formula: CC₁₄D₅H₁₉O₅

Color and Shape: Off-White

Molecular weight: 290.372

Ref: TR-D465985