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CAS 71939-51-0

:

α-Artemether

Description:
α-Artemether is an antimalarial compound derived from artemisinin, which is extracted from the sweet wormwood plant, Artemisia annua. It is primarily used in the treatment of malaria, particularly in cases caused by Plasmodium falciparum, the most severe malaria parasite. The compound is characterized by its rapid action against the malaria parasite, making it effective in reducing the parasite load in the bloodstream. α-Artemether is typically administered in combination with other antimalarial drugs to enhance efficacy and reduce the risk of resistance. It is a lipophilic compound, which influences its absorption and distribution in the body. The substance is usually formulated as an injectable solution or in oral dosage forms. Its mechanism of action involves the generation of reactive oxygen species upon activation in the presence of iron, leading to the disruption of the parasite's cellular processes. While generally well-tolerated, potential side effects may include dizziness, nausea, and allergic reactions. Overall, α-Artemether plays a crucial role in malaria treatment regimens, particularly in regions with high resistance to other antimalarial drugs.
Formula:C16H26O5
InChI:InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,14-,15-,16-/m1/s1
InChI key:InChIKey=SXYIRMFQILZOAM-CNNNLJIRSA-N
SMILES:C[C@@H]1[C@]2([C@]34[C@](O[C@H]1OC)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]
Synonyms:
  • (+)-a-Artemether
  • (3R,5aS,6R,8aS,9R,10R,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
  • 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin,decahydro-10-methoxy-3,6,9-trimethyl-, [3R-(3a,5ab,6b,8ab,9a,10b,12b,12aR*)]-
  • Sm 229
  • a-Dihydroartemisinin methyl ether
  • 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
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