CAS 71939-51-0
:α-Artemether
Description:
α-Artemether is an antimalarial compound derived from artemisinin, which is extracted from the sweet wormwood plant, Artemisia annua. It is primarily used in the treatment of malaria, particularly in cases caused by Plasmodium falciparum, the most severe malaria parasite. The compound is characterized by its rapid action against the malaria parasite, making it effective in reducing the parasite load in the bloodstream. α-Artemether is typically administered in combination with other antimalarial drugs to enhance efficacy and reduce the risk of resistance. It is a lipophilic compound, which influences its absorption and distribution in the body. The substance is usually formulated as an injectable solution or in oral dosage forms. Its mechanism of action involves the generation of reactive oxygen species upon activation in the presence of iron, leading to the disruption of the parasite's cellular processes. While generally well-tolerated, potential side effects may include dizziness, nausea, and allergic reactions. Overall, α-Artemether plays a crucial role in malaria treatment regimens, particularly in regions with high resistance to other antimalarial drugs.
Formula:C16H26O5
InChI:InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,14-,15-,16-/m1/s1
InChI key:InChIKey=SXYIRMFQILZOAM-CNNNLJIRSA-N
SMILES:C[C@@H]1[C@]2([C@]34[C@](O[C@H]1OC)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]
Synonyms:- (+)-a-Artemether
- (3R,5aS,6R,8aS,9R,10R,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin,decahydro-10-methoxy-3,6,9-trimethyl-, [3R-(3a,5ab,6b,8ab,9a,10b,12b,12aR*)]-
- Sm 229
- a-Dihydroartemisinin methyl ether
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
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Found 10 products.
α-ARTEMETHER RS
CAS:α-ARTEMETHER RSFormula:C16H26O5Color and Shape:Added ModifiedMolecular weight:298.3746Artemether Related Compound B ((3R,5aS,6R,8aS,9R,10R,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin)
CAS:Heterocyclic compounds with oxygen hetero-atom(s) onlyFormula:C16H26O5Color and Shape:White Solid PowderMolecular weight:298.17802Methyl 8-(3-octyloxiran-2-yl)octanoate
CAS:Methyl 8-(3-octyloxiran-2-yl)octanoatePurity:≥98%Molecular weight:312.49g/molArtemether USP Related Compound B (α-Artemether)
CAS:Formula:C16H26O5Color and Shape:Pale Yellow SolidMolecular weight:298.38a-Artemether
CAS:Impurity Artemether USP Related Compound B
Applications Derivative of Artemisinin (A777500). Shows antimalarial and antifungal activity.
References Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011), Galal, A. et al.: J. Nat. Prod. 68, 1274 (2005)Formula:C16H26O5Color and Shape:Off-WhiteMolecular weight:298.37α-Artemether-13C, D3
CAS:Formula:C1513CH23D3O5Color and Shape:White to Off-White SolidMolecular weight:302.39a-Artemether
CAS:a-Artemether is a sesquiterpene lactone that is active against amoebae. It has been shown to be effective in the treatment of infectious diseases such as malaria and toxoplasmosis. a-Artemether has long-term toxicity, which may be due to its ability to cause hepatic steatosis. A study on drug interactions found that a-artemether can inhibit the activity of cytochrome P450 enzymes, resulting in lower plasma concentrations of drugs that are substrates for these enzymes.Formula:C16H26O5Purity:Min. 95%Molecular weight:298.37 g/molα-Artemether
CAS:alpha-Artemether is a Quinghaosu derivative with antifungal and antimalarial activity.Formula:C16H26O5Purity:98%Color and Shape:SolidMolecular weight:298.37
