CAS 7195-27-9

mefruside

Description:

Mefruside, with the CAS number 7195-27-9, is a chemical compound classified as a sulfonamide. It is primarily recognized for its diuretic properties, which make it useful in the treatment of conditions such as hypertension and edema. Mefruside functions by inhibiting sodium reabsorption in the kidneys, leading to increased urine output and a reduction in blood volume. The compound is typically administered in oral form and is known for its relatively rapid onset of action. In terms of its chemical structure, mefruside contains a sulfonamide group, which is characteristic of many diuretics, and it may exhibit various functional groups that contribute to its pharmacological activity. As with many medications, potential side effects can include electrolyte imbalances, dehydration, and allergic reactions. It is essential for patients to be monitored while on mefruside to ensure safety and efficacy. Overall, mefruside is an important agent in the management of certain cardiovascular conditions, reflecting the broader role of sulfonamides in medicinal chemistry.

Formula: C₁₃H₁₉ClN₂O₅S₂

InChI: InChI=1/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18)

InChI key: InChIKey=SMNOERSLNYGGOU-UHFFFAOYSA-N

SMILES: C(N(S(=O)(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1)C)C2(C)CCCO2

Synonyms:

• 1,3-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-((tetrahydro-2-methyl-2-furanyl)methyl)-
• 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-((tetrahydro-2-methyl-2-furanyl)methyl)-
• 1,3-Benzenedisulfonamide, 4-chloro-N¹-methyl-N¹-[(tetrahydro-2-methyl-2-furanyl)methyl]-
• 4-Chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N-methyl-N-(2-methyltetrahydrofurfuryl)-1,3-benzenesulfonamide
• 4-Chloro-N¹-methyl-N¹-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N¹-methyl-N¹-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
• 4-chloro-N~1~-methyl-N~1~-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
• B 1500
• Bay 1500
• Baycaron
• Fba 1500
• Fda 1902
• Mefrusal
• Mefrusid
• Mefrusida
• Mefrusida [INN-Spanish]
• Mefruside [USAN:INN:BAN:JAN]
• Mefrusidum
• Mefrusidum [INN-Latin]
• N-(4'-Chloro-3'-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran
• N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine
• m-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-
• m-Benzenedisulfonamide, 4-chloro-N¹-methyl-N¹-(tetrahydro-2-methylfurfuryl)-
• Mefruside
• m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-
• 4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
• 4-Chloro-N-methyl-N-(tetrahydro-2-methylfuran-2-yl)-1,3-benzenedisulfonamide
• 4-chloro-N-methyl-N-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
• 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]- (9CI)
• 4-chloro-1-N-methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide
• mefruside USP/EP/BP
• 4-chloro-N1-methyl-N1-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide

Mefruside 1.0 mg/ml in Methanol

CAS: 7195-27-9

Color and Shape: Single Solution

Ref: 61-AMP1399.00-01

Mefruside

CAS: 7195-27-9

Formula: C₁₃H₁₉ClN₂O₅S₂

Molecular weight: 382.89

Ref: 4Z-M-144001

Mefruside

Controlled Product

CAS: 7195-27-9

Stability Hygroscopic
Applications Mefruside is a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Formula: C₁₃H₁₉ClN₂O₅S₂

Color and Shape: Off-White

Molecular weight: 382.88

Ref: TR-M205150

Mefruside-d3

Controlled Product

CAS: 7195-27-9

Stability Hygroscopic
Applications Isotope labelled analogue of Mefruside (M205150), a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Formula: C₁₃H₁₆D₃ClN₂O₅S₂

Color and Shape: White To Light Beige

Molecular weight: 385.90

Ref: TR-M205152

Mefruside

CAS: 7195-27-9

Mefruside is a drug that belongs to the class of anti-inflammatory drugs and is used to treat bowel disease, cardiac diseases, and blood vessel diseases. Mefruside has been shown to be effective in treating infectious diseases and lowering diastolic pressure. Mefruside lowers systolic pressure by acid formation and prevents autoimmune diseases. It also has long-term efficacy for blood sampling and glomerular filtration rate, as well as inflammatory bowel disease. Mefruside may cause liver cell damage and high sodium levels in the body.

Formula: C₁₃H₁₉ClN₂O₅S₂

Purity: Min. 95%

Molecular weight: 382.9 g/mol

Ref: 3D-HAA19527

Mefruside

CAS: 7195-27-9

Mefruside is a diuretic indicated for the treatment of edema and hypertension.

Formula: C₁₃H₁₉ClN₂O₅S₂

Color and Shape: Solid

Molecular weight: 382.88

Ref: TM-T33276