CAS 71963-77-4

Artemether

Description:

Artemether is an antimalarial compound derived from artemisinin, which is extracted from the sweet wormwood plant, Artemisia annua. It is primarily used in the treatment of malaria, particularly for cases caused by Plasmodium falciparum, including drug-resistant strains. Artemether is characterized by its rapid action against the malaria parasite, making it effective in reducing the severity of symptoms. The compound is typically administered in combination with lumefantrine to enhance efficacy and reduce the risk of resistance. Chemically, artemether is a sesquiterpene lactone with a complex structure that includes an endoperoxide bridge, which is crucial for its antimalarial activity. It is generally well-tolerated, but potential side effects may include nausea, vomiting, and dizziness. Artemether is usually available in oral formulations, but it can also be administered via intramuscular injection in severe cases. Its use is a key component of combination therapy strategies recommended by the World Health Organization to combat malaria effectively.

Formula: C₁₆H₂₆O₅

InChI: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

InChI key: InChIKey=SXYIRMFQILZOAM-HVNFFKDJSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@](O[C@@H]1OC)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]

Synonyms:

• (1R,4S,5R,8S,9R,10S,12R,13R)-10-Methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0~4,13~.0~8,13~]hexadecane
• (3R,5aS,6R,8aS,9R,10R,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
• (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
• (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
• (4S,5R,8S,9R,10S,12R,13R)-10-Methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0~4,13~.0~8,13~]hexadecane
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10α,12β,12aR*)]-
• 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
• 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (5aS,6R,8aS,9R,10S,12R,12aR)-
• Artemetero
• Artemether [INN]
• Artemetherum
• Artemos
• Artenam
• Artesaph
• Artesian
• Dihydroartemisinin methyl ether
• Falcidol
• Gvither
• Larither
• Malartem
• Paluther
• Sm 224
• β-Artemether
• β-Dihydroartemisinin methyl ether

Artemether

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 298.38

Ref: 3B-A2190

ARTEMETHER RS

CAS: 71963-77-4

ARTEMETHER RS

Formula: C₁₆H₂₆O₅

Color and Shape: Added Modified

Molecular weight: 298.3746

Ref: 41-ICRS1408

Artemether

CAS: 71963-77-4

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi

Formula: C₁₆H₂₆O₅

Color and Shape: White Crystalline Powder

Molecular weight: 298.17802

Ref: 45-1042780

Artemether

CAS: 71963-77-4

Artemether (CGP 56696) is an antimalarial agent used to treat acute uncomplicated malaria.

Formula: C₁₆H₂₆O₅

Purity: 99.87% - 99.93%

Color and Shape: Solid

Molecular weight: 298.37

Ref: TM-T1323

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 298.3746

Ref: IN-DA00IKIW

Artemether

CAS: 71963-77-4

Artemether

Purity: ≥98%

Molecular weight: 298.37g/mol

Ref: 54-BUP16738

Artemether

CAS: 71963-77-4

Artemether

Purity: 98%

Molecular weight: 298.37g/mol

Ref: 54-OR1029058

Artemether

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 298.37

Ref: 7W-GL9620

Artemether

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Molecular weight: 298.38

Ref: 4Z-A-115003

Artemether

Controlled Product

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Color and Shape: Neat

Molecular weight: 298.37

Ref: 86-MM3252.00

Artemether

CAS: 71963-77-4

Formula: C₁₆H₂₆O₅

Purity: 95%~99%

Molecular weight: 298.379

Ref: BP-BP0195

Artemether- 13C, d3

Controlled Product

CAS: 71963-77-4

Applications Artemether- 13C, d3, is the labeled analogue of Artemether (A777400), which is a derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),

Formula: CC₁₅D₃H₂₃O₅

Color and Shape: Neat

Molecular weight: 302.386

Ref: TR-A777403

Artemether

CAS: 71963-77-4

Artemether is an antimalarial medication, which is derived from the natural source Artemisia annua, a plant traditionally used in Chinese medicine. This compound is a semi-synthetic derivative of the plant's active ingredient, artemisinin.

Formula: C₁₆H₂₆O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 298.37 g/mol

Ref: 3D-FA17991

Artemether

CAS: 71963-77-4

Purity: 98%

Molecular weight: 298.38

Ref: 10-F795474

Artemether

CAS: 71963-77-4

Applications Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),

Formula: C₁₆H₂₆O₅

Color and Shape: White to Off-White Solid

Molecular weight: 298.37

Ref: TR-A777400