CAS 71965-57-6
:Globotriaosylceramide
Description:
Globotriaosylceramide (Gb3 or GL-3) is a glycosphingolipid characterized by its structure, which consists of a ceramide backbone linked to a trisaccharide composed of galactose and glucose units. It is primarily found in the membranes of various cell types and plays a significant role in cellular recognition and signaling processes. Gb3 is particularly notable for its association with certain diseases, including Fabry disease, a genetic disorder resulting from the deficiency of the enzyme alpha-galactosidase A, leading to the accumulation of Gb3 in various tissues. This accumulation can cause a range of symptoms, including pain, kidney dysfunction, and cardiovascular issues. In addition to its biological significance, Gb3 has been studied for its role in pathogen interactions, as some viruses and bacteria exploit glycosphingolipids for cell entry. The substance is also of interest in the field of biochemistry and pharmacology for its potential therapeutic implications and as a biomarker for certain conditions.
Formula:Unspecified
InChI:InChI=1/C54H99NO18/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-42(60)55-37(38(59)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)36-68-52-48(66)45(63)50(40(34-57)70-52)73-54-49(67)46(64)51(41(35-58)71-54)72-53-47(65)44(62)43(61)39(33-56)69-53/h17-18,29,31,37-41,43-54,56-59,61-67H,3-16,19-28,30,32-36H2,1-2H3,(H,55,60)/b18-17+,31-29+
Synonyms:- 71965-57-6
- Cd 77
- Ceramide trihexoside
- Ceramide, 1-O-(O-α-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→4)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-β-<smallcap>D</span>-glucopyranosyl)-
- Fabry glycolipid
- Ganglioside G<sub>L3</sub>
- Ganglioside Gb<sub>3</sub>
- Gb<sub>3</sub>
- Gb<sub>3</sub>Cer
- Globo-N-triaosylceramide
- Globotriaosylceramide
- Globotriglycosylceramide
- Globotriosylceramide
- Shiga toxin receptor
- Trihexosylceramide
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 5 products.
Globotriaosylceramides (porcine)
CAS:<p>Globotriaosylceramides, cell membrane glycosphingolipids, act as Shiga toxin receptors and accumulate in Fabry disease, resisting HIV by blocking gp120.</p>Formula:C60H113NO18Color and Shape:SolidMolecular weight:1136.553Globotriaosylceramide
CAS:<p>It is one of the few clusters of differentiation that is not a protein and structurally contains a galactose moiety linked α to lactosylceramide. Defects in the enzyme α-galactosidase lead to the buildup of globotriaosylceramide, causing Fabry's disease. The pharmaceutical drug migalastat enhances the function of α-galactosidase and is used to treat Fabry's. Globotriaosylceramide is also one of the targets of Shiga toxin, which is responsible for pathogenicity of enterohemorrhagic E. coli.</p>Formula:C60H113NO18Purity:Min. 95%Color and Shape:PowderMolecular weight:1135.79577
