CAS 71989-23-6

N-Fmoc-L-isoleucine

Description:

N-Fmoc-L-isoleucine is a derivative of the amino acid isoleucine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protective group on the amino terminus. This compound is commonly used in peptide synthesis as a building block due to its stability and ease of removal of the Fmoc group under mild basic conditions. N-Fmoc-L-isoleucine retains the essential properties of isoleucine, including its hydrophobic nature and ability to participate in various interactions within peptide chains. The Fmoc group enhances the solubility of the amino acid in organic solvents, facilitating its incorporation into peptides. Additionally, N-Fmoc-L-isoleucine is typically white to off-white in appearance and is soluble in common organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Its molecular structure allows for the formation of stable peptide bonds, making it a valuable component in the synthesis of biologically active peptides and proteins.

Formula: C₂₁H₂₃NO₄

InChI: InChI=1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1

InChI key: InChIKey=QXVFEIPAZSXRGM-DJJJIMSYSA-N

SMILES: C(OC(N[C@@H]([C@H](CC)C)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• (2S,3R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoate
• (2S,3S)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-methylpentanoic acid
• 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid
• <span class="text-smallcaps">L</span>-Isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• Fmoc-Ile-OH
• Fmoc-L-isoleucine
• Fmoc-lle-OH
• N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-isoleucine
• N-(9-Fluorenylmethoxycarbonyl)isoleucine
• N-Fmoc-<span class="text-smallcaps">L</span>-isoleucine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-isoleucine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]isoleucin
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]isoleucine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alloisoleucine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucine
• NSC 334289
• isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine
• L-Isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine

CAS: 71989-23-6

Formula: C₂₁H₂₃NO₄

Color and Shape: White to Almost white powder to crystal

Molecular weight: 353.42

Ref: 3B-F0294

Fmoc-Ile-OH

CAS: 71989-23-6

Bachem ID: 4003168.

Formula: C₂₁H₂₃NO₄

Purity: 99.87%

Color and Shape: White

Molecular weight: 353.42

Ref: 01-4003168

Fmoc-L-Isoleucine

CAS: 71989-23-6

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 353.4116

Ref: IN-DA0036PS

Fmoc-Ile-OH

CAS: 71989-23-6

Fmoc-Ile-OH

Purity: ≥98%

Molecular weight: 353.41g/mol

Ref: 54-BUP19430

Fmoc-Ile-OH

CAS: 71989-23-6

Formula: C₂₁H₂₃NO₄

Purity: ≥ 99.0%

Color and Shape: White powder

Molecular weight: 353.42

Ref: 7W-GM4384

Fmoc-lle-OH

CAS: 71989-23-6

M03362 - Fmoc-lle-OH

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Powder or Crystalline Powder

Molecular weight: 353.418

Ref: 10-M03362

Fmoc-Ile-OH

CAS: 71989-23-6

Fmoc-Ile-OH (Fmoc-L-isoleucine) is an Fmoc-modified isoleucine with a strong affinity for peptides and proteins and can be used to synthesize other active

Formula: C₂₁H₂₃NO₄

Purity: 99.75%

Color and Shape: Solid

Molecular weight: 353.41

Ref: TM-T67562

L-Isoleucine, FMOC protected

CAS: 71989-23-6

L-Isoleucine, FMOC protected

Formula: C₂₁H₂₃NO₄

Purity: 95%

Color and Shape: white powder

Molecular weight: 353.41g/mol

Ref: 54-OR0490

Fmoc-Ile-OH (N-Fmoc-L-isoleucine)

CAS: 71989-23-6

Formula: C₂₁H₂₃NO₄

Molecular weight: 353.42

Ref: 4Z-L-117014

Fmoc-Ile-OH

CAS: 71989-23-6

Fmoc-Ile-OH is a sodium salt that is used in the synthesis of peptides. It provides the hydroxyl group to the peptide chain, and can be used in solid-phase synthesis. The protonated form of Fmoc-Ile-OH is useful for acetonitrile solvents. Fmoc-Ile-OH has shown antibacterial activity against gram-positive bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. Clinical development of this drug has been successful in treating infections caused by multidrug resistant bacteria, such as MRSA, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Formula: C₂₁H₂₃NO₄

Purity: Min. 98.0 Area-%

Molecular weight: 353.42 g/mol

Ref: 3D-FLI-1724-PI

FMOC-L-Isoleucine extrapure, 99%

CAS: 71989-23-6

Formula: C₂₁H₂₃NO₄

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 353.40

Ref: SR-22834

N-Fmoc-L-isoleucine

Controlled Product

CAS: 71989-23-6

Applications N-Fmoc-L-isoleucine is a N-Fmoc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.
References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Formula: C₂₁H₂₃NO₄

Color and Shape: Neat

Molecular weight: 353.41

Ref: TR-F625025

N-Fmoc-L-isoleucine-d10

Controlled Product

CAS: 71989-23-6

Applications N-Fmoc-L-isoleucine-d10 is the labeled analogue of N-Fmoc-L-isoleucine (F625025), a N-Fmoc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.
References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Formula: C₂₁D₁₀H₁₃NO₄

Color and Shape: Neat

Molecular weight: 363.473

Ref: TR-F625027

Fmoc-Ile-OH

CAS: 71989-23-6

Fmoc-Ile-OH is a cyclic peptide that has shown cytotoxic activity against cultured human brain cells. It is also an inhibitor of dipeptidyl peptidase IV (DPP-IV) and inhibits the breakdown of proteins in the brain, such as insulin. Fmoc-Ile-OH binds to the active site of DPP-IV and prevents it from binding to its substrate, thereby inhibiting the enzyme's activity. The inhibition of DPP-IV leads to increased levels of protein in the brain, which may be beneficial for people with Alzheimer's disease. Fmoc-Ile-OH is synthesized on a solid phase by coupling an amino acid with a protected carboxylic acid to yield a protected amide. This product can be used as an encapsulating agent for atosiban, a drug that is used to treat preterm labor.END>>

Formula: C₂₁H₂₃NO₄

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 353.41 g/mol

Ref: 3D-FF15881