CAS 71989-28-1

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine

Description:

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine, commonly referred to as Fmoc-L-methionine, is a derivative of the amino acid methionine, modified with a fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is primarily utilized in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where the Fmoc group serves as a protective moiety for the amino group of the amino acid. The Fmoc group is stable under basic conditions but can be easily removed under mildly acidic conditions, allowing for selective deprotection during peptide assembly. Fmoc-L-methionine is characterized by its relatively high stability, solubility in organic solvents, and compatibility with various coupling reagents used in peptide synthesis. Additionally, methionine is an essential amino acid, playing a crucial role in protein synthesis and various metabolic processes. The presence of the fluorenyl group enhances the compound's photophysical properties, making it useful in applications involving fluorescence. Overall, Fmoc-L-methionine is a valuable building block in the field of biochemistry and pharmaceutical research.

Formula: C₂₀H₂₁NO₄S

InChI: InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m0/s1

InChI key: InChIKey=BUBGAUHBELNDEW-SFHVURJKSA-N

SMILES: C(OC(N[C@@H](CCSC)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid
• (2S)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-4-(methylsulfanyl)butanoic acid
• (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid
• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-(methylsulfanyl)butanoate
• (S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylsulfanylbutanoic acid
• (S)-N-Fmoc-methionine
• 224: PN: US20070042401 PAGE: 30 claimed protein
• 915: PN: WO2006135786 PAGE: 59 claimed protein
• <span class="text-smallcaps">L</span>-Fmoc-Methionine
• <span class="text-smallcaps">L</span>-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• FMOC-methionine
• Fmoc-L-Met-OH
• Fmoc-Met-OH
• N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-methionine
• N-(9-Fluorenylmethoxycarbonyl)-L-methionine
• N-(9-Fluorenylmethoxycarbonyl)methionine
• N-Fluorenylmethoxycarbonyl-<span class="text-smallcaps">L</span>-methionine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-methionine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine
• N-alpha-FMOC-L-methionine
• NSC 334292
• N-Fluorenylmethoxycarbonyl-L-methionine

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 371.45

Ref: 3B-F0296

Fmoc-Met-OH

CAS: 71989-28-1

M03368 - Fmoc-Met-OH

Formula: C₂₀H₂₁NO₄S

Purity: 98%

Color and Shape: Solid, Powder or Crystalline Powder

Molecular weight: 371.45

Ref: 10-M03368

Fmoc-Met-OH

CAS: 71989-28-1

Bachem ID: 4003154.

Formula: C₂₀H₂₁NO₄S

Purity: 99.67%

Color and Shape: White

Molecular weight: 371.46

Ref: 01-4003154

N-Fmoc-L-Methionine

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 371.4500

Ref: IN-DA00IC7J

Fmoc-Met-OH

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Purity: ≥ 98.0%

Color and Shape: White to almost white powder or colourless crystals

Molecular weight: 371.46

Ref: 7W-GM6487

N-Fmoc-L-Methionine

CAS: 71989-28-1

N-Fmoc-L-Methionine

Purity: 98%

Molecular weight: 371.45g/mol

Ref: 54-OR1014375

Fmoc-Met-OH

CAS: 71989-28-1

Fmoc-Met-OH

Purity: ≥98%

Molecular weight: 371.45g/mol

Ref: 54-BUP19872

L-Methionine-d3-N-FMOC(S-methyl-d3)

CAS: 502692-58-2, 71989-28-1

Formula: CD₃SCH₂CH₂CH(NHFMOC)COOH

Purity: 98 atom % D

Color and Shape: White Solid.

Molecular weight: 374.47

Ref: 3U-D6625

Fmoc-Met-OH

CAS: 71989-28-1

Fmoc-Met-OH (Fmoc-L-Met-OH) is an fmoc-based programmed synthesis of methionine derivatives.

Formula: C₂₀H₂₁NO₄S

Purity: 99.55%

Color and Shape: Solid

Molecular weight: 371.45

Ref: TM-T67568

N-Fmoc-L-Methionine-34S

CAS: 71989-28-1

Formula: SC₂₀H₂₁NO₄

Molecular weight: 373.36

Ref: 4Z-M-473

N-Fmoc-L-Methionine

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Molecular weight: 371.45

Ref: 4Z-M-472

Fmoc-Met-OH

CAS: 71989-28-1

Fmoc-Met-OH is an amino acid that has significant cytotoxicity. It is a neutral molecule with a pKa of 7.6, and is soluble in water at low pH. The hydrogen bonding interactions of Fmoc-Met-OH are strong and involve the amino group and the side chain carboxyl groups, as well as other hydrophobic interactions with aromatic rings. Fmoc-Met-OH is also an acid analysis reagent for chlorine atoms because it can be easily converted to methoxychlor (CHClO). Fmoc-Met-OH has been shown to inhibit epidermal growth factor receptor signaling and has been used to block epidermal growth factor induced cell cycle progression in cancer cells.

Formula: C₂₀H₂₁NO₄S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 371.5 g/mol

Ref: 3D-FF06001

FMOC-L-Methionine extrapure, 99%

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 371.46

Ref: SR-50606

L-Fmoc-Methionine- 34S

Controlled Product

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Color and Shape: Neat

Molecular weight: 373.35

Ref: TR-F403960

Fmoc-Met-OH

CAS: 71989-28-1

Formula: C₂₀H₂₁NO₄S

Molecular weight: 371.5

Ref: ST-EA-CP-L28028