CAS 72-14-0

Sulfathiazole

Description:

Sulfathiazole is a sulfonamide antibiotic that belongs to the class of compounds known as sulfa drugs. It is characterized by its thiazole ring structure, which is fused to a sulfanilamide moiety. This compound exhibits antibacterial properties by inhibiting bacterial folic acid synthesis, thereby interfering with the growth and reproduction of bacteria. Sulfathiazole is typically used in the treatment of various bacterial infections, particularly those caused by Gram-positive organisms. It is soluble in water and has a relatively low melting point, which facilitates its use in pharmaceutical formulations. The compound is often administered orally or topically, depending on the type of infection being treated. However, its use has declined with the advent of more effective antibiotics and concerns regarding resistance. Sulfathiazole may also have side effects, including allergic reactions and gastrointestinal disturbances. Overall, it remains an important historical compound in the development of antimicrobial therapies.

Formula: C₉H₉N₃O₂S₂

InChI: InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)

InChI key: InChIKey=JNMRHUJNCSQMMB-UHFFFAOYSA-N

SMILES: S(NC1=NC=CS1)(=O)(=O)C2=CC=C(N)C=C2

Synonyms:

• 2-(P-Aminobenzenesulfonamido)Thiazole
• 2-(Sulfanilylamino)thiazole
• 2-(p-Aminobenzenesulphonamido)thiazole
• 2-Sulfanilamidothiazole
• 2-Sulfathiazole
• 2090 R.P.
• 4-Amino-N-2-Thiazolyl-Benzenesulfonamide
• 4-Amino-N-2-thiazolylbenzenesulfonamide
• 4-Amino-N-2-thiazolylbenzensulfonamide
• 4-[(1,3-Thiazol-2-yl)aminosulfonyl]aniline
• 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide
• Azoquimiol
• Azoseptale
• Benzenesulfonamide, 4-amino-N-2-thiazolyl-
• Chemosept
• Ciba 3714
• Cibazol
• Duatok
• Dulana
• Eleudron
• Enterobiocine
• Estafilol
• M and B 760
• M&B 760
• N'-2-thiazolylsulfanylamide
• N-(Thiazol-2-yl)-4-aminobenzenesulfonamide
• N1-(2-Thiazolyl)sulfanilamide
• N¹-(2-Thiazolyl)sulfanilamide
• Neostrepsan
• Norsulfasol
• Norsulfazol
• Norsulfazole
• Nsc 31812
• Nsc 683531
• Planomide
• Poliseptil
• ST
• Sanotiazol
• Streptosilthiazole
• Sulfamul
• Sulfanilamide, N1-2-thiazolyl-
• Sulfanilamide, N1-4-thiazolin-2-ylidene-
• Sulfanilamide, N¹-2-thiazolyl-
• Sulfanilamide, N¹-4-thiazolin-2-ylidene-
• Sulfanilamidothiazole
• Sulfanilamine, N1-2-Thiazolyl-
• Sulfathiazol
• Sulfathiazole
• Sulfathiazole Granule
• Sulfatiazol
• Sulfavitina
• Sulfocerol
• Sulphathiazole
• Sulzol
• Thiacoccine
• Thiasulfol
• Thiazamide
• Thiozamide
• Wintrazole

Sulfathiazole

Controlled Product

CAS: 72-14-0

Applications Antibacterial.This compound is a contaminant of emerging concern (CECs).
References Kapoor, V.K., et al.: Anal. Profiles Drug Subs. Excip., 22, 389 (1993),

Formula: C₉H₉N₃O₂S₂

Color and Shape: Neat

Molecular weight: 255.32

Ref: TR-S699093

Sulfathiazole in Methanol

CAS: 72-14-0

Methanol

Ref: BE-BePure-25705XM-100

Sulfathiazole in Acetonitrile

CAS: 72-14-0

Acetonitrile

Ref: BE-BePure-25705YA-1000

Sulfathiazole

CAS: 72-14-0

Ref: BE-BePure-25705

4-Amino-N-(thiazol-2-yl)benzenesulfonamide

CAS: 72-14-0

Formula: C₉H₉N₃O₂S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 255.31

Ref: 10-F222582

Sulfathiazole

CAS: 72-14-0

4-Amino-N-(thiazol-2-yl)benzenesulfonamide

Formula: C₉H₉N₃O₂S₂

Purity: 98+%

Molecular weight: 255.32

Ref: IN-DG152183

Sulfathiazole

CAS: 72-14-0

Sulfathiazole is a sulfonamide antibacterial agent with a chemical structure similar to that of the sulfa drugs. It is active against Gram-positive and Gram-negative bacteria, including those resistant to other antibiotics. Sulfathiazole has been shown to be effective against infectious diseases caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella typhi. The mechanism of action of sulfathiazole is not fully understood. One hypothesis is that it inhibits the synthesis of folic acid in bacteria by inhibiting enzymes involved in purine metabolism. This drug also has complex pharmacological effects on human cells because it can inhibit both receptor activity and enzyme activity in complex cellular processes such as protein synthesis and DNA synthesis.

Formula: C₉H₉N₃O₂S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 255.32 g/mol

Ref: 3D-FS27944