CAS 72-23-1

11-Dehydrocorticosterone

Description:

11-Dehydrocorticosterone is a steroid hormone that is a derivative of corticosterone, primarily involved in the regulation of various physiological processes, including metabolism and immune response. It is classified as a glucocorticoid, which means it plays a significant role in glucose metabolism and has anti-inflammatory properties. The chemical structure of 11-dehydrocorticosterone features a steroid backbone with specific functional groups that contribute to its biological activity. This compound is produced in the adrenal cortex and is involved in the synthesis of other corticosteroids. Its CAS number, 72-23-1, uniquely identifies it in chemical databases. In terms of solubility, it is generally lipophilic, allowing it to easily cross cell membranes and exert its effects on target tissues. The hormone's activity is mediated through its interaction with glucocorticoid receptors, influencing gene expression and cellular responses. Due to its physiological significance, 11-dehydrocorticosterone is of interest in both clinical and research settings, particularly in studies related to stress response and endocrine disorders.

Formula: C₂₁H₂₈O₄

InChI: InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1

InChI key: InChIKey=FUFLCEKSBBHCMO-KJQYFISQSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3=O)[C@@H](C(CO)=O)CC4)[H])(CCC1=CC(=O)CC2)[H])[H]

Synonyms:

• 11-Dehydrocorticosteron
• 11-Dehydrocorticosterone
• 11-Oxo-11-deoxycorticosterone
• 11-Oxocorticosterone
• 17-(1-keto-2-Hydroxyethyl)-Δ⁴-androsten-3,11-dione
• 21-Hydroxypregn-4-Ene-3,11,20-Trione
• 4-Pregnen-21-ol-3,11,20-trione
• Corticosterone, 11-dehydro-
• Dehydrocorticosterone
• Kendall's compound A
• Nsc-9702
• Pregn-4-ene-3,11,20-trione, 21-hydroxy-
• Δ⁴-Pregnen-21-ol-3,11,20-trione

11-Dehydro Corticosterone-d10

CAS: 72-23-1

Formula: C₂₁H₁₈D₁₀O₄

Molecular weight: 354.51

Ref: 4Z-C-10416

11-Dehydro Corticosterone

CAS: 72-23-1

Formula: C₂₁H₂₈O₄

Color and Shape: White To Off-White Solid

Molecular weight: 344.45

Ref: 4Z-C-1044

11-Dehydrocorticosterone

Controlled Product

CAS: 72-23-1

Applications 11-Dehydrocorticosterone is a precursor to corticosterone (C695700), converted by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which plays a role in glucocorticoid-induced insulin resistance.
References Morgan, S. et al.: Diabetes, 58, 2506 (2009);

Formula: C₂₁H₂₈O₄

Color and Shape: White To Light Yellow

Molecular weight: 344.44

Ref: TR-D230115

11-Dehydrocorticosterone-13C3

Controlled Product

CAS: 72-23-1

Formula: C₃C₁₈H₂₈O₄

Color and Shape: Neat

Molecular weight: 344.44

Ref: TR-D230118

11-Dehydrocorticosterone-13C3

Controlled Product

CAS: 72-23-1

11-Dehydrocorticosterone-13C3 is a synthetic glucocorticoid that is used as a nasal drug. It has been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor and interleukin-1β, which are involved in the pathogenesis of autoimmune diseases. 11-Dehydrocorticosterone-13C3 binds to the glucocorticoid receptor with high affinity and specificity and possesses a hydroxyl group at C3 position. It is effective in inhibiting the production of proinflammatory cytokines in 3T3-L1 preadipocytes by blocking the function of nuclear factor kappa B (NFκB). It also inhibits the release of colony stimulating factors, such as granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), from 3t3-l1 preadipocytes.

Formula: C₂₁H₂₈O₄

Purity: Min. 95%

Molecular weight: 347.42 g/mol

Ref: 3D-AAA07223

11-Dehydrocorticosterone

CAS: 72-23-1

11-Dehydrocorticosterone is a metabolite of corticosteroids and a sodium-retaining agent, increasing the expression of SGK mRNA in cardiac fibroblasts.

Formula: C₂₁H₂₈O₄

Color and Shape: Solid

Molecular weight: 344.45

Ref: TM-T68808

11-Dehydrocorticosterone

CAS: 72-23-1

Formula: C₂₁H₂₈O₄

Molecular weight: 344.45

Ref: ST-EA-CP-C244002