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CAS 72007-47-7

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ala-pro-gly-(ile3,val5)-angiotensin ii

Description:
Ala-Pro-Gly-(Ile3,Val5)-angiotensin II, with the CAS number 72007-47-7, is a synthetic peptide that is a modified form of angiotensin II, a key regulator in the renin-angiotensin system, which plays a crucial role in blood pressure regulation and fluid balance. This peptide consists of a sequence of amino acids, including alanine (Ala), proline (Pro), glycine (Gly), isoleucine (Ile), and valine (Val), indicating specific substitutions at positions 3 and 5 of the angiotensin II structure. The modifications in the amino acid sequence can influence its biological activity, receptor binding affinity, and stability. Typically, peptides like this one are studied for their potential therapeutic applications in cardiovascular diseases, hypertension, and related disorders. They may exhibit altered pharmacokinetics and pharmacodynamics compared to the native angiotensin II, making them valuable in research and clinical settings. As with many peptides, stability, solubility, and bioavailability are important characteristics that can affect their efficacy as therapeutic agents.
Formula:C60H86N16O15
InChI:InChI=1/C60H86N16O15/c1-6-33(4)49(74-50(81)39(15-10-22-65-60(62)63)69-51(82)41(28-47(79)80)68-46(78)30-66-53(84)44-16-11-23-75(44)57(88)34(5)61)56(87)70-40(25-36-18-20-38(77)21-19-36)52(83)73-48(32(2)3)55(86)71-42(27-37-29-64-31-67-37)58(89)76-24-12-17-45(76)54(85)72-43(59(90)91)26-35-13-8-7-9-14-35/h7-9,13-14,18-21,29,31-34,37,39-45,48-49,77H,6,10-12,15-17,22-28,30,61H2,1-5H3,(H,66,84)(H,68,78)(H,69,82)(H,70,87)(H,71,86)(H,72,85)(H,73,83)(H,74,81)(H,79,80)(H,90,91)(H4,62,63,65)/t33-,34-,37?,39-,40-,41-,42-,43-,44-,45-,48-,49-/m0/s1
Synonyms:
  • Ala-pro-gly-(3-ile-5-val)-angiotensin II
  • L-Phenylalanine, N-(1-(N-(N-(N-(N-(N(2)-(N-(N-(1-L-alanyl-L-prolyl)glycyl)-L-alpha-aspartyl)-L-arginyl)-L-isoleucyl)-L-tyrosyl)-L-valyl)-L-histidyl)-L-prolyl)-
  • Ala-Pro-Gly-Asp-Arg-Ile-Tyr-Val-His-Pro-Phe
  • Angiotensin II, ala-pro-gly-(ile(3)-val(5))-
  • Crinia-angiotensin
  • L-alanyl-L-prolylglycyl-L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-isoleucyl-L-tyrosyl-L-valyl-3-(4H-imidazol-4-yl)-L-alanyl-L-prolyl-L-phenylalanine
  • Angiotensin II, alanyl-prolyl-glycyl-(isoleucyl(3)-valine(5))-
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