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CAS 72025-60-6

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leukotriene C4

Description:
Leukotriene C4 (LTC4) is a potent lipid mediator involved in inflammatory responses and is part of the leukotriene family, which are derived from arachidonic acid. It is characterized by its role in bronchoconstriction, increased vascular permeability, and the recruitment of immune cells, particularly in conditions such as asthma and allergic reactions. LTC4 is a cysteinyl leukotriene, meaning it contains a cysteine residue, which contributes to its biological activity. It is typically synthesized by various immune cells, including mast cells and eosinophils, through the action of lipoxygenase enzymes. The substance is known to bind to specific leukotriene receptors, leading to various physiological effects. In terms of its chemical structure, LTC4 is a tripeptide composed of glutathione, which is modified by the addition of a leukotriene moiety. Due to its significant role in mediating inflammatory processes, LTC4 is a target for therapeutic interventions aimed at managing allergic and inflammatory diseases.
Formula:C30H47N3O9S
InChI:InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
InChI key:InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N
SMILES:[C@@H](CS[C@@H]([C@H](CCCC(O)=O)O)/C=C/C=C/C=C\C/C=C\CCCCC)(NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
Synonyms:
  • 5S,6R-LTC<sub>4</sub>
  • 5S,6R-Ltc(sub 4)
  • <span class="text-smallcaps">L</smallcap>-γ-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-<smallcap>L</span>-cysteinylglycine
  • Glycine, <span class="text-smallcaps">L</smallcap>-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-<smallcap>L</span>-cysteinyl-
  • Glycine, <span class="text-smallcaps">L</smallcap>-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-<smallcap>L</span>-cysteinyl-
  • Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))-
  • Glycine, N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-<span class="text-smallcaps">L</smallcap>-γ-glutamyl-<smallcap>L</span>-cysteinyl]-, [R-[R*,S*-(E,E,Z,Z)]]-
  • L-gamma-glutamyl-S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine
  • LTC (sub 4)
  • LTC<sub>4</sub>
  • See more synonyms
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