CAS 7206-76-0

Phenylethylmalonamide

Description:

Phenylethylmalonamide, with the CAS number 7206-76-0, is an organic compound characterized by its structure, which includes a phenyl group and a malonamide moiety. This compound typically appears as a white to off-white solid and is known for its potential applications in pharmaceuticals and organic synthesis. It exhibits moderate solubility in polar solvents, which is common for amides due to their ability to form hydrogen bonds. The presence of both the phenyl and malonamide groups contributes to its unique chemical reactivity, allowing it to participate in various chemical reactions, such as acylation and amidation. Additionally, phenylethylmalonamide may exhibit biological activity, making it of interest in medicinal chemistry. Its stability under standard conditions is generally good, although it may be sensitive to strong acids or bases. Overall, phenylethylmalonamide is a versatile compound with significant implications in both synthetic and medicinal chemistry.

Formula: C₁₁H₁₄N₂O₂

InChI: InChI=1S/C11H14N2O2/c1-2-11(9(12)14,10(13)15)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,12,14)(H2,13,15)

InChI key: InChIKey=JFZHPFOXAAIUMB-UHFFFAOYSA-N

SMILES: C(C(N)=O)(C(N)=O)(CC)C1=CC=CC=C1

Synonyms:

• 2-Ethyl-2-Phenylmalonamide
• 2-Ethyl-2-Phenylmalondiamide
• 2-Ethyl-2-Phenylpropanediamide
• 2-Ethyl-2-Phenylpropanediamide Hydrate
• 2-Methyl-2-Phenylbutanamide
• 2-Phenyl-2-Ethylmalonamide
• 2-Phenyl-2-Ethylmalondiamide
• Ethylphenylmalondiamide
• Malonamide, 2-ethyl-2-phenyl-
• PEMA monohydrate
• Pema
• Pema (Amide)
• Phenylethylmalonamide
• Phenylethylmalondiamide

Primidone Related Compound A (2-Ethyl-2-phenylmalonamide)

CAS: 7206-76-0

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₁₁H₁₄N₂O₂

Color and Shape: White Crystalline Powder

Molecular weight: 206.10553

Ref: 45-1562011

Primidone EP Impurity A (Primidone USP Related Compound A)

CAS: 7206-76-0

Formula: C₁₁H₁₄N₂O₂

Molecular weight: 206.25

Ref: 4Z-P-356

2-Ethyl-2-phenylmalonamide

CAS: 7206-76-0

Impurity Primaquine USP Related Compound A
Applications A metabolite of Primidone. Primaquine USP Related Compound A.
References Holler, M., et al.: Biochem. Pharmacol., 33, 1753 (1984), Lafont, O., et al.: Eur. J. Med. Chem., 25, 61 (1990), Fisher, J., et al.: Pharmacol. Res., 26, 207 (1992), Florence, A., et al.: Pharmacol. Res., 14, 259 (1997), El-Masri, H., et al.: Drug Metab. Dispos., 26, 585 (1998),

Formula: C₁₁H₁₄N₂O₂

Color and Shape: White To Off-White

Molecular weight: 206.24

Ref: TR-E925455

2-Ethyl-2-phenylmalonamide

CAS: 7206-76-0

2-Ethyl-2-phenylmalonamide (2-EPMA) is a metabolite of primidone that acts as an inhibitor of glutamate dehydrogenase and may be used in the treatment of epilepsy. It has been shown to be effective in treating seizures caused by carbamazepine, phenobarbital, or phenytoin. 2-EPMA is also used to measure enzyme activities in serum, which can be used as a diagnostic tool for liver diseases. 2-EPMA is typically prepared for use as an enzyme inhibitor by diluting it with high salt or human serum. This compound may have carcinogenic potential and should not be administered with single doses greater than 100 mg/kg body weight. 2-EPMA interacts with many other drugs such as phenobarbital, phenytoin, and carbamazepine.

Formula: C₁₁H₁₄N₂O₂

Purity: Min. 95%

Molecular weight: 206.24 g/mol

Ref: 3D-FE23105

Primidone EP Impurity A

CAS: 7206-76-0

Formula: C₁₁H₁₄N₂O₂

Molecular weight: 206.24

Ref: ST-EA-CP-P131001