CAS 72063-39-9

Spinosin

Description:

Spinosin, with the CAS number 72063-39-9, is a natural compound primarily derived from the plant species *Ziziphus jujuba*, commonly known as jujube. It belongs to the class of flavonoids and is recognized for its potential pharmacological properties. Spinosin is characterized by its unique chemical structure, which includes a flavone backbone, contributing to its bioactivity. This compound has garnered interest in the field of herbal medicine due to its reported anxiolytic, sedative, and neuroprotective effects. Additionally, spinosin exhibits antioxidant properties, which may help in mitigating oxidative stress in biological systems. Its solubility profile suggests it is more soluble in organic solvents than in water, which can influence its bioavailability and therapeutic applications. Research into spinosin continues to explore its mechanisms of action and potential benefits in treating various health conditions, particularly those related to anxiety and sleep disorders. Overall, spinosin represents a significant area of interest in natural product chemistry and pharmacology.

Formula: C₂₈H₃₂O₁₅

InChI: InChI=1S/C28H32O15/c1-39-14-7-15-18(12(32)6-13(40-15)10-2-4-11(31)5-3-10)22(35)19(14)26-27(24(37)21(34)16(8-29)41-26)43-28-25(38)23(36)20(33)17(9-30)42-28/h2-7,16-17,20-21,23-31,33-38H,8-9H2,1H3/t16-,17-,20-,21-,23+,24+,25-,26+,27-,28+/m1/s1

InChI key: InChIKey=VGGSULWDCMWZPO-ODEMIOGVSA-N

SMILES: O(C)C1=C(C(O)=C2C(=C1)OC(=CC2=O)C3=CC=C(O)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4

Synonyms:

• (1S)-1,5-Anhydro-2-O-beta-D-glucopyranosyl-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol
• 4H-1-Benzopyran-4-one, 6-(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 4H-1-Benzopyran-4-one, 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 6-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• D-glucitol, 1,5-anhydro-2-O-beta-D-glucopyranosyl-1-C-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-
• Flavoayamenin
• Spinosin
• Swertisin 2′′-O-glucoside
• 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 6-(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-

Spinosin

CAS: 72063-39-9

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₂₈H₃₂O₁₅

Color and Shape: Yellow Powder

Molecular weight: 608.17412

Ref: 45-1618717

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 608.5447

Ref: IN-DA00FBG1

Spinosin

CAS: 72063-39-9

Spinosin

Purity: ≥98%

Molecular weight: 608.54g/mol

Ref: 54-BUP00112

Spinosin

CAS: 72063-39-9

Spinosin

Purity: 95%

Molecular weight: 608.54g/mol

Ref: 54-OR1024110

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Molecular weight: 608.55

Ref: 7W-GY0454

Spinosin

CAS: 72063-39-9

Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.

Formula: C₂₈H₃₂O₁₅

Purity: 95%~99%

Molecular weight: 608.549

Ref: BP-BP1336

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 608.55

Ref: 3B-P2887

Spinosin

CAS: 72063-39-9

1.

Formula: C₂₈H₃₂O₁₅

Purity: 98.16% - 99.75%

Color and Shape: Solid

Molecular weight: 608.54

Ref: TM-T6S2227

Spinosin

CAS: 72063-39-9

Natural glycoside

Formula: C₂₈H₃₂O₁₅

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 608.55

Ref: 5G-83284

Spinosin

Controlled Product

CAS: 72063-39-9

Applications Spinosin is a C-glycoside flavonoid extracted from Zizhiphi Spinozae, improved pentobarbital-induced sleep.
References Wang, Li. et al.: Pharm. Biochem. Behav., 90, 399 (2008);

Formula: C₂₈H₃₂O₁₅

Color and Shape: Neat

Molecular weight: 608.54

Ref: TR-S681950

Spinosin

CAS: 72063-39-9

Spinosin is a natural product that belongs to the group of pyrrolizidine alkaloids. It has been shown to have physiological function as it can inhibit the 5-HT1A receptor and thereby regulate neurotransmitter release. Spinosin also has anti-inflammatory effects and can be used in the treatment of skin disorders, such as psoriasis. In vitro studies have shown that spinosin is a substrate for P-gp and interacts with other drugs by inhibiting their absorption in the gut and liver. Spinosin has been found to bind to monoclonal antibodies, which may be due to its structural similarity to chinese herb, a known antigenic protein. This leads to increased uptake of spinosin into cells and thus makes it an analytical method for measuring spinosin in biological samples. Spinosin activates p38mapk which then causes the phosphorylation of ERK1/2, leading to receptor binding and activation of downstream signaling pathways.

Formula: C₂₈H₃₂O₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 608.54 g/mol

Ref: 3D-FS65586