CAS 72080-89-8

Carbamic acid, [(1S)-1-[(dimethylamino)carbonyl]-3-methylbutyl]-,1,1-dimethylethyl ester

Description:

Carbamic acid, [(1S)-1-[(dimethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester, identified by CAS number 72080-89-8, is an organic compound characterized by its carbamate functional group. This substance features a complex structure that includes a dimethylamino group and a branched alkyl chain, contributing to its unique chemical properties. It is typically a colorless to pale yellow liquid with a moderate boiling point and is soluble in organic solvents. The presence of the dimethylamino group suggests potential basicity, while the carbamate moiety indicates reactivity typical of esters and amides. This compound may exhibit biological activity, making it of interest in pharmaceutical applications. Its stability can be influenced by environmental factors such as pH and temperature, and it may undergo hydrolysis in the presence of water. Safety data should be consulted for handling and storage, as with any chemical substance, to ensure proper precautions are taken.

Formula: C₁₃H₂₆N₂O₃

N-[(1S)-1-[(Dimethylamino)carbonyl]-3-methylbutyl]-carbamic Acid 1,1-Dimethylethyl Ester

Controlled Product

CAS: 72080-89-8

Applications N-[(1S)-1-[(Dimethylamino)carbonyl]-3-methylbutyl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (S)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt which is an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Formula: C₁₃H₂₆N₂O₃

Color and Shape: Neat

Molecular weight: 258.36

Ref: TR-D470788

Carfilzomib Impurity 47

CAS: 72080-89-8

Formula: C₁₃H₂₆N₂O₃

Molecular weight: 258.36

Ref: ST-EA-CP-C153041