CAS 72143-20-5

4-[bis(2-hydroxyethyl)amino]-L-phenylalanine

Description:

4-[Bis(2-hydroxyethyl)amino]-L-phenylalanine, also known by its CAS number 72143-20-5, is an amino acid derivative characterized by the presence of a phenylalanine backbone modified with two hydroxyethyl groups attached to a nitrogen atom. This compound features a chiral center, which contributes to its potential biological activity and interactions. The hydroxyethyl groups enhance its solubility in water and may influence its pharmacokinetic properties, making it of interest in pharmaceutical applications. The presence of hydroxyl groups can also facilitate hydrogen bonding, potentially affecting its interactions with biological macromolecules. As a derivative of L-phenylalanine, it retains the essential amino acid properties, which may be relevant in protein synthesis and metabolic pathways. Its unique structure suggests potential applications in drug design, particularly in developing compounds that require enhanced solubility and bioavailability. However, specific studies on its biological activity and therapeutic potential would be necessary to fully understand its implications in medicinal chemistry.

Formula: C₁₃H₂₀N₂O₄

InChI: InChI=1/C13H20N2O4/c14-12(13(18)19)9-10-1-3-11(4-2-10)15(5-7-16)6-8-17/h1-4,12,16-17H,5-9,14H2,(H,18,19)/t12-/m0/s1

SMILES: c1cc(ccc1C[C@@H](C(=O)O)N)N(CCO)CCO

Synonyms:

• L-phenylalanine, 4-[bis(2-hydroxyethyl)amino]-
• 4-[Bis(2-hydroxyethyl)amino]-L-phenylalanine

Melphalan EP Impurity A (Dihydroxy Melphalan)

CAS: 72143-20-5

Formula: C₁₃H₂₀N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 268.31

Ref: 4Z-M-857

Dihydroxy Melphalan

CAS: 72143-20-5

Dihydroxy melphalan, an inactive byproduct of melphalan, forms in water-based solutions like human plasma.

Formula: C₁₃H₂₀N₂O₄

Color and Shape: Solid

Molecular weight: 268.313

Ref: TM-T36751

Dihydroxy Melphatalan

Controlled Product

CAS: 72143-20-5

Applications Dihydroxy Melphatalan is an analogue of Melphalan (M216900), an antineoplastic.
References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980);

Formula: C₁₃H₂₀N₂O₄

Color and Shape: Neat

Molecular weight: 268.31

Ref: TR-D452895

Dihydroxy Melphatalan-d8

Controlled Product

CAS: 72143-20-5

Formula: C₁₃D₈H₁₂N₂O₄

Color and Shape: Neat

Molecular weight: 276.358

Ref: TR-D452897

Dihydroxy melphatalan

CAS: 72143-20-5

Please enquire for more information about Dihydroxy melphatalan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₃H₂₀N₂O₄

Purity: Min. 95%

Molecular weight: 268.31 g/mol

Ref: 3D-FD182659

Melphalan EP Impurity A

CAS: 72143-20-5

Formula: C₁₃H₂₀N₂O₄

Molecular weight: 268.31

Ref: ST-EA-CP-M9001

Dihydroxy melphatalan-d8

CAS: 72143-20-5

Dihydroxy melphalan-d8 is a cytostatic drug that has potent anticancer effects. It can be used as a chemotherapeutic agent in the treatment of chronic lymphocytic leukemia and cervical cancer. Dihydroxy melphalan-d8 can be synthesized by reacting melphalan with d8-2,3-diaminonaphthalene in the presence of base to form the nitrogen mustard dihydroxy melphalan. The drug is then purified by chromatographic techniques such as HPLC or high performance liquid chromatography (HPLC). Dihydroxymelphaland8 has been shown to bind to DNA and inhibit DNA replication. This inhibition prevents cells from dividing, which leads to cell death. The terminal half-life of this drug is approximately 8 hours.

Formula: C₁₃H₂₀N₂O₄

Purity: Min. 95%

Molecular weight: 268.31 g/mol

Ref: 3D-XCA14320