CAS 72194-57-1

5-oxo-L-prolyl-L-prolyl-N~5~-(diaminomethylidene)-N-(4-nitrophenyl)-L-ornithinamide

Description:

5-Oxo-L-prolyl-L-prolyl-N~5~-(diaminomethylidene)-N-(4-nitrophenyl)-L-ornithinamide, with the CAS number 72194-57-1, is a synthetic compound that belongs to the class of amino acid derivatives. This substance features a complex structure characterized by multiple functional groups, including amide and nitrophenyl moieties, which contribute to its potential biological activity. The presence of the 5-oxo group suggests that it may participate in various chemical reactions, possibly influencing its reactivity and stability. The diaminomethylidene group indicates potential for interactions with biological targets, making it of interest in medicinal chemistry. Its structural components may also impart specific solubility and polarity characteristics, affecting its pharmacokinetics and bioavailability. While specific applications or biological activities may vary, compounds of this nature are often explored for their roles in drug development, particularly in targeting enzymes or receptors involved in metabolic pathways. Further studies would be necessary to elucidate its precise mechanisms of action and therapeutic potential.

Formula: C₂₂H₃₀N₈O₆

InChI: InChI=1/C22H30N8O6/c23-22(24)25-11-1-3-15(19(32)26-13-5-7-14(8-6-13)30(35)36)28-20(33)17-4-2-12-29(17)21(34)16-9-10-18(31)27-16/h5-8,15-17H,1-4,9-12H2,(H,26,32)(H,27,31)(H,28,33)(H4,23,24,25)/t15-,16-,17-/m0/s1

SMILES: C(C[C@@H](C(=O)Nc1ccc(cc1)N(=O)=O)N=C([C@@H]1CCCN1C(=O)[C@@H]1CCC(=N1)O)O)CNC(=N)N

Synonyms:

• Pyr-Pro-Arg-Pna

Pyr-Pro-Arg-pNA

CAS: 72194-57-1

The chromogenic substrate pEPR-pNA has been used for the determination of kinetic constants of tryptase (EC 3.4.21.59) from guinea pig (Km = 0.24 – 0.26 mM) and human (Km = 0.24 – 0.43 mM). Pyr-Pro-Arg-pNA has also been used as substrate for the coagulation factor XIa. Km and kcat values for this substrate were 0.56 mM and 350 s⁻¹, respectively.

Formula: C₂₂H₃₀N₈O₆

Purity: > 95%

Color and Shape: Yellow Powder

Molecular weight: 502.53

Ref: 01-4034068

Pyr-Pro-Arg-pNA hydrochloride salt

CAS: 72194-57-1

Pyr-Pro-Arg-pNA hydrochloride salt is a chromogenic substrate that is used to detect microorganisms in the blood. This substrate is activated by the enzyme ochraceous, which catalyzes the hydrolysis of pyr-pro-arg-pNA. The reaction produces hydrogen peroxide and an orange color. Pyr-Pro-Arg-pNA hydrochloride salt can be used as an anticoagulant for blood plasma samples. It can also be used to identify Aspergillus ochraceus, a fungus that causes pulmonary infections in humans. Aspergillus ochraceus has been shown to produce this enzyme and to have a high affinity for this substrate.

Formula: C₂₂H₃₀N₈O₆·HCl

Purity: Min. 95%

Molecular weight: 538.98 g/mol

Ref: 3D-FP110821