CAS 722492-56-0

Ferumoxytol

Description:

Ferumoxytol is an iron-based nanoparticle formulation primarily used as an intravenous iron replacement therapy for patients with iron deficiency anemia, particularly those with chronic kidney disease. It is characterized by its unique composition, consisting of superparamagnetic iron oxide nanoparticles coated with a carbohydrate shell, which enhances its stability and biocompatibility. Ferumoxytol has a high iron content, allowing for the administration of larger doses in a shorter time compared to traditional iron supplements. Its superparamagnetic properties also make it useful in magnetic resonance imaging (MRI) as a contrast agent. The substance is generally well-tolerated, with a lower incidence of allergic reactions compared to other intravenous iron formulations. However, it may cause side effects such as hypotension, nausea, and dizziness. Ferumoxytol's mechanism of action involves the release of iron into the bloodstream, where it can be utilized for hemoglobin synthesis and other vital biological processes. Overall, Ferumoxytol represents a significant advancement in the treatment of iron deficiency anemia, particularly in patients with specific medical conditions.

Synonyms:

• Ferumoxytol [USAN]
• C 7228
• Code 7228
• Cytogen
• Feraheme
• Ferrheme

Ferumoxytol

CAS: 722492-56-0

Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.

Color and Shape: Solid

Ref: TM-T207484

Ferumoxytol

CAS: 722492-56-0

Ferumoxytol is used in magnetic resonance imaging (MRI) to improve the quality of images. It is given intravenously and is excreted unchanged by the kidneys. Ferumoxytol has been shown to be safe and effective for diagnosing bowel disease, including Crohn's disease, ulcerative colitis, and diverticulitis. Ferumoxytol also has been shown to be useful in evaluating cardiac function before and after myocardial infarction. Ferumoxytol has a low toxicity profile with no significant adverse effects reported during clinical trials.

Formula: Fe₃H₂O₄

Purity: Min. 95%

Molecular weight: 233.55 g/mol

Ref: 3D-FF45918