CAS 722543-31-9

Barasertib

Description:

Barasertib, also known by its chemical name AZD1152, is a small molecule inhibitor primarily targeting Aurora B kinase, an enzyme involved in cell division. It is classified as an antineoplastic agent, making it relevant in cancer research and treatment. Barasertib exhibits characteristics typical of kinase inhibitors, including the ability to disrupt mitotic processes, leading to cell cycle arrest and apoptosis in cancer cells. Its mechanism of action involves competitive inhibition, which prevents the phosphorylation of target proteins necessary for mitosis. The substance is often studied in the context of various malignancies, particularly those with aberrant Aurora B activity. Barasertib is typically administered in a clinical setting, and its pharmacokinetics include absorption, distribution, metabolism, and excretion profiles that are crucial for determining dosing regimens. Safety and efficacy are evaluated through clinical trials, where side effects and therapeutic outcomes are closely monitored. Overall, Barasertib represents a promising avenue in targeted cancer therapy, particularly for tumors that are resistant to conventional treatments.

Formula: C₂₆H₃₁FN₇O₆P

InChI: InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)

InChI key: InChIKey=GBJVVSCPOBPEIT-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCCN(CCOP(=O)(O)O)CC)C=C2)N=CN1)C3=CC(CC(NC4=CC(F)=CC=C4)=O)=NN3

Synonyms:

• AZD1152
• Barasertib
• 5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
• AZD 1152
• 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide

CAS: 722543-31-9

Formula: C₂₆H₃₁FN₇O₆P

Purity: 98%

Molecular weight: 587.5398

Ref: IN-DA00FBZC

Barasertib

CAS: 722543-31-9

Barasertib

Purity: ≥98%

Molecular weight: 587.54g/mol

Ref: 54-BUP02137

Barasertib

CAS: 722543-31-9

AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.

Formula: C₂₆H₃₁FN₇O₆P

Purity: 99.63% - 99.92%

Color and Shape: Solid

Molecular weight: 587.54

Ref: TM-T14371

AZD 1152

CAS: 722543-31-9

AZD 1152 is an Aurora kinase inhibitor, which is a type of small-molecule therapeutic agent. It is derived from the pharmaceutical research conducted by AstraZeneca. Its primary mode of action involves the selective inhibition of Aurora B kinase, an enzyme crucial for the regulation of mitosis. By interfering with this enzyme, AZD 1152 disrupts the normal progression of cell division, leading to the inhibition of proliferation and induction of apoptosis in rapidly dividing cells.

Formula: C₂₆H₃₁FN₇O₆P

Purity: Min. 97 Area-%

Color and Shape: Slightly Yellow Powder

Molecular weight: 587.54 g/mol

Ref: 3D-FE18067

Barasertib

Controlled Product

CAS: 722543-31-9

Formula: C₂₆H₃₁FN₇O₆P

Color and Shape: Neat

Molecular weight: 587.55

Ref: TR-B129135