CAS 7226-77-9

2'-deoxy-5-(hydroxymethyl)cytidine

Description:

2'-Deoxy-5-(hydroxymethyl)cytidine, commonly referred to as DHM-C, is a nucleoside analog characterized by its structural similarity to the natural nucleoside cytidine. It features a hydroxymethyl group at the 5-position of the pyrimidine ring, which distinguishes it from standard cytidine. This modification can influence its biological activity, particularly in the context of nucleic acid synthesis and antiviral properties. The presence of the deoxyribose sugar moiety indicates that it is a component of DNA rather than RNA. DHM-C has garnered interest in medicinal chemistry and molecular biology due to its potential applications in therapeutic agents, particularly in the treatment of viral infections and cancer. Its solubility and stability in biological systems are critical for its efficacy, and it may exhibit unique interactions with DNA polymerases and other enzymes involved in nucleic acid metabolism. Overall, 2'-deoxy-5-(hydroxymethyl)cytidine represents a significant compound in the study of nucleoside analogs and their applications in biochemistry and pharmacology.

Formula: C₁₀H₁₅N₃O₅

InChI: InChI=1/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1

Synonyms:

• Cytidine, 2'-deoxy-5-(hydroxymethyl)-
• 5-Hydroxymethyl-2'-deoxycytidine

2'-Deoxy-5-(hydroxymethyl)cytidine

CAS: 7226-77-9

Formula: C₁₀H₁₅N₃O₅

Purity: >98.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 257.25

Ref: 3B-D4220

Cytidine, 2'-​deoxy-​5-​(hydroxymethyl)​-

CAS: 7226-77-9

Formula: C₁₀H₁₅N₃O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 257.2432

Ref: IN-DA00FCVU

5-Hydroxymethyl-2'-deoxycytidine

CAS: 7226-77-9

5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations,

Formula: C₁₀H₁₅N₃O₅

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 257.24

Ref: TM-T40834

5-Hydroxymethyl-2'-deoxycytidine

CAS: 7226-77-9

5-Hydroxymethyl-2'-deoxycytidine

Purity: ≥98%

Molecular weight: 257.24g/mol

Ref: 54-BUP09400

2'-Deoxy-5-(hydroxymethyl)cytidine

CAS: 7226-77-9

Formula: C₁₀H₁₅N₃O₅

Molecular weight: 257.25

Ref: 4Z-C-4511

5-Hydroxymethyl-2''-deoxycytidine

CAS: 7226-77-9

Ref: 7W-GN9819

5-(Hydroxymethyl)-2'-deoxycytidine-d3

Controlled Product

CAS: 7226-77-9

Applications Labelled 4-(Hydroxymethyl)-2’-deoxycytidine, a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples.
References Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);

Formula: C₁₀H₁₂D₃N₃O₅

Color and Shape: White

Molecular weight: 260.26

Ref: TR-H946632

5-(Hydroxymethyl)-2’-deoxycytidine

Controlled Product

CAS: 7226-77-9

Applications 4-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples
References Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);

Formula: C₁₀H₁₅N₃O₅

Color and Shape: Neat

Molecular weight: 257.24

Ref: TR-H946630

2'-Deoxy-5-hydroxymethylcytidine

CAS: 7226-77-9

2'-Deoxy-5-hydroxymethylcytidine is a nucleoside analog that inhibits the enzyme thymidylate synthase. The inhibition of this enzyme leads to a deficiency in the production of thymine, which is essential for DNA synthesis. 2'-Deoxy-5-hydroxymethylcytidine has been shown to be an effective anti-cancer agent in vitro and in vivo. It can also be used as a potential biomarker for cancer and can be used as a polymerase chain reaction (PCR) primer for detection of cancer tissue. This drug binds to the polymerase enzyme, preventing it from performing its function to replicate DNA, thereby halting cell division and causing cell death.

Formula: C₁₀H₁₅N₃O₅

Purity: Min. 95%

Color and Shape: White Yellow Powder

Molecular weight: 257.24 g/mol

Ref: 3D-NH15898