CAS 7240-37-1

7-Aminoactinomycin D

Description:

7-Aminoactinomycin D is a potent anthracycline antibiotic and chemotherapeutic agent, primarily known for its role in cancer treatment. It is derived from the bacterium *Streptomyces* and is characterized by its ability to intercalate into DNA, thereby inhibiting RNA synthesis and disrupting cellular processes. The compound features a complex structure that includes a polypeptide chain and a chromophore, which contributes to its biological activity. 7-Aminoactinomycin D exhibits fluorescence properties, making it useful in various laboratory applications, including cell viability assays and DNA quantification. Its mechanism of action involves binding to the guanine-cytosine base pairs in DNA, leading to the induction of apoptosis in rapidly dividing cells, which is particularly beneficial in oncology. However, its use is associated with potential side effects, including myelosuppression and gastrointestinal disturbances. As a result, careful dosing and monitoring are essential during treatment. Overall, 7-Aminoactinomycin D remains a significant compound in cancer research and therapy, highlighting the importance of natural products in medicinal chemistry.

Formula: C₆₂H₈₇N₁₃O₁₆

InChI: InChI=1/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)

SMILES: CC(C)C1C(=O)N2CCCC2C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC(C)C(C(=N1)O)N=C(c1cc(c(C)c2c1nc1c(c(c(=O)c(C)c1o2)N)C(=NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)N=C1O)O)N)O

Synonyms:

• 7-amino-AMD
• Actinomycin D, 7-amino-
• Flu 402
• Nsc 239759
• 2,7-diamino-4,6-dimethyl-3-oxo-N,N'-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• Actinomycin D, 7-Amino- - CAS 7240-37-1 - Calbiochem
• 7-AMINOACTINOMYCIN D USP/EP/BP
• 7-AAD
• 7-AAD [7-Aminoactinomycin D] *CAS 7240-37-1*
• 7-AMINODACTINOMYCIN
• 7-ADD
• 7-AMINOACTINOMYCIN C1
• 7-AMINOACTINOMYCIN
• 7-AAD/CH85402
• 7-AMINOACTINOMYCIN D
• 7-ACTINOMYCIN C

7-Aminoactinomycin D

CAS: 7240-37-1

7-Aminoactinomycin D is a fluorescent DNA stain.

Formula: C₆₂H₈₇N₁₃O₁₆

Purity: 98%

Color and Shape: Red To Dark Purple Powder

Molecular weight: 1270.453

Ref: TM-T18906

7-Aminoactinomycin D

CAS: 7240-37-1

7-Aminoactinomycin D

Formula: C₆₂H₈₇N₁₃O₁₆

Purity: By hplc: 97.08% (240nm); 98.96% (Typical Value in Batch COA)

Color and Shape: Dark Purple Powder

Molecular weight: 1,270.43g/mol

Ref: 54-BIA4306

7-Aminoactinomycin D

CAS: 7240-37-1

Formula: C₆₂H₈₇N₁₃O₁₆

Purity: ≥ 96.0%

Color and Shape: Red to dark purple powder

Molecular weight: 1270.43

Ref: 7W-GA3296

7-Aminoactinomycin D

CAS: 7240-37-1

7-Aminoactinomycin D is a fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis, as it is generally excluded by live cells

Formula: C₆₂H₈₇N₁₃O₁₆

Purity: Min. 95%

Molecular weight: 1,270.43 g/mol

Ref: 3D-FA146843