CAS 7246-14-2

Methicillin hydrate sodium salt

Description:

Methicillin hydrate sodium salt, with the CAS number 7246-14-2, is a semi-synthetic antibiotic belonging to the penicillin class. It is primarily used to treat infections caused by penicillinase-producing staphylococci. This compound is characterized by its ability to resist degradation by certain beta-lactamase enzymes, which makes it effective against specific bacterial strains. Methicillin is typically administered in its sodium salt form to enhance solubility and bioavailability. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its use in clinical settings. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Methicillin is not commonly used today due to the emergence of methicillin-resistant Staphylococcus aureus (MRSA), but it remains a significant historical antibiotic in the study of antibiotic resistance. Proper storage conditions are essential to maintain its stability, and it should be handled with care in a laboratory setting.

Formula: C₁₇H₂₀N₂O₆S·H₂O·Na

InChI: InChI=1S/C17H20N2O6S.Na.H2O/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);;1H2/t11-,12+,15-;;/m1../s1

InChI key: InChIKey=QUEIUUMFENOQSD-HWROMZCQSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C3=C(OC)C=CC=C3OC)C2=O)(SC1(C)C)[H].[Na].O

Synonyms:

• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
• Methicillin Sodium
• Methicillin hydrate sodium salt
• Methicillin sodium hydrate
• Methicillin sodium salt hydrate
• Sodium 2,6-dimethoxyphenylpenicillin hydrate
• Sodium 6-(2,6-Dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylate hydrate
• Sodium 6-(2,6-Dimethoxybenzamido)Penicillanate
• Sodium 6-(2,6-dimethoxybenzamido)penicillanate monohydrate
• Sodium 6-[(2,6-Dimethoxybenzoyl)Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
• Sodium methicillin hydrate
• Sodium methicillin monohydrate
• sodium (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Methicillin sodium hydrate

CAS: 7246-14-2

Methicillin sodium hydrate, a narrow-spectrum antibiotic, combats methicillin-resistant Staphylococcus strains and treats various infections.

Formula: C₁₇H₂₁N₂NaO₇S

Color and Shape: Solid

Molecular weight: 420.41

Ref: TM-T73859

Methicillin sodium hydrate

CAS: 7246-14-2

Methicillin sodium hydrate is a semi-synthetic β-lactam antibiotic, which is a derivative of the naturally occurring antibiotic penicillin. It is sourced from the modification of the penicillin nucleus, specifically designed to resist degradation by the bacterial enzyme penicillinase. This enzyme, produced by certain bacterial strains, can render penicillin ineffective. Methicillin operates by inhibiting the synthesis of bacterial cell walls, specifically binding to penicillin-binding proteins (PBPs). This action disrupts the cross-linking of peptidoglycan chains, a critical component for bacterial cell wall integrity, ultimately leading to cell lysis and death.

Formula: C₁₇H₂₁N₂NaO₇S

Purity: Min. 95%

Molecular weight: 420.4 g/mol

Ref: 3D-HAA24614