CAS 72509-76-3: Felodipine
Description:Felodipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by selectively inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle during depolarization, leading to vasodilation and reduced blood pressure. Felodipine is characterized by its lipophilic nature, which enhances its absorption and bioavailability. The compound typically appears as a yellow crystalline solid and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics are influenced by factors such as food intake, which can affect its absorption. Felodipine is metabolized in the liver, primarily by cytochrome P450 enzymes, and its metabolites are excreted mainly through urine. Common side effects may include peripheral edema, headache, and flushing. Due to its mechanism of action, felodipine is effective in managing cardiovascular conditions, but it should be used with caution in patients with certain pre-existing conditions or those taking specific medications that may interact with its metabolism.
Formula:C18H19Cl2NO4
InChI:InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key:InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES:O=C(OC)C1=C(NC(=C(C(=O)OCC)C1C=2C=CC=C(Cl)C2Cl)C)C
- Synonyms:
- H 154/82
- Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- Felodipine
- Plendil
- 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
- 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
- 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
- 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
- ,ethylmethylester
- Felodipin
- See more synonyms
- Agon
- 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
- FelodipineUsp25DmfGmp
- dl-Felodipine
- h154/82
- Hydac
- (RS)-Felodipine
- Splendil
- modip
- ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
- FEXOFENADINE HCL
- Munobal

Felodipine
Ref: 3B-F0814
1g | 107.00 € | ||
5g | 350.00 € |

Felodipine
Ref: 02-J61195
50mg | To inquire | ||
100mg | To inquire | ||
250mg | To inquire |

Felodipine
Ref: 47-777
100mg | 242.00 € |

Ref: 41-F0030000
100mg | 115.00 € |

Ref: 47-758
20mg | 211.00 € |

Felodipine

Felodipine
Ref: IN-DA005SL4
1g | 49.00 € | ||
5g | 68.00 € | ||
10g | 122.00 € | ||
25g | 182.00 € | ||
100g | 303.00 € |

Felodipine
Ref: TM-T0145
5mg | 51.00 € | ||
10mg | 82.00 € | ||
25mg | 124.00 € | ||
50mg | 180.00 € | ||
100mg | 264.00 € | ||
200mg | 398.00 € | ||
500mg | 647.00 € | ||
1mL*10mM (DMSO) | 90.00 € |

Felodipine
Ref: 7W-GP8252
1g | 99.00 € | ||
5g | 292.00 € |

3-Ethyl 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
Ref: 54-OR1010981
5g | 51.00 € | ||
25g | 171.00 € | ||
100g | 390.00 € | ||
500g | 1,209.00 € |

Ref: 54-BUP15014
1g | 1,037.00 € | ||
10mg | 114.00 € | ||
25mg | 180.00 € | ||
50mg | 261.00 € | ||
100mg | 375.00 € | ||
500mg | 877.00 € |

Ref: 4Z-F-132
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |

Felodipine-d3 (2,3-dichlorophenyl-d3)
Ref: 3U-D7175
5mg | 703.00 € | ||
10mg | 1,179.00 € |

Felodipine 100 µg/mL in Acetonitrile
Ref: 04-A13407800AL-100
1ml | 106.00 € |

Ref: 04-C13407800
100mg | To inquire |

Ref: 4Z-F-135
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |

Felodipine-13C4, d3
Controlled ProductRef: TR-F232376
1mg | 318.00 € | ||
10mg | 2,062.00 € |

Felodipine
Ref: TR-F232375
5mg | 122.00 € | ||
10mg | 137.00 € | ||
25mg | 180.00 € |

Felodipine
Ref: 10-M06306
1g | 36.00 € | ||
5g | 82.00 € | ||
10g | 139.00 € | ||
25g | 240.00 € | ||
100g | 540.00 € | ||
500g | To inquire |

Felodipine - Bio-X ™
Ref: 3D-BF164445
10mg | 135.00 € |

rac Felodipine-13C4
Controlled ProductRef: TR-F232379
25mg | 8,684.00 € |

Felodipine
Ref: 3D-FF23238
25g | 205.00 € | ||
50g | 307.00 € | ||
100g | 479.00 € | ||
250g | 812.00 € | ||
500g | 1,376.00 € |