CAS 72509-76-3

Felodipine

Description:

Felodipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by selectively inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle during depolarization, leading to vasodilation and reduced blood pressure. Felodipine is characterized by its lipophilic nature, which enhances its absorption and bioavailability. The compound typically appears as a yellow crystalline solid and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics are influenced by factors such as food intake, which can affect its absorption. Felodipine is metabolized in the liver, primarily by cytochrome P450 enzymes, and its metabolites are excreted mainly through urine. Common side effects may include peripheral edema, headache, and flushing. Due to its mechanism of action, felodipine is effective in managing cardiovascular conditions, but it should be used with caution in patients with certain pre-existing conditions or those taking specific medications that may interact with its metabolism.

Formula: C₁₈H₁₉Cl₂NO₄

InChI: InChI=1/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key: InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(Cl)C(Cl)=CC=C2

Synonyms:

• H 154/82
• Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Felodipine
• Plendil
• 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
• 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
• ,ethylmethylester
• Felodipin
• Agon
• 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
• FelodipineUsp25DmfGmp
• dl-Felodipine
• h154/82
• Hydac
• (RS)-Felodipine
• Splendil
• modip
• ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
• FEXOFENADINE HCL

Felodipine-13C4, d3

Controlled Product

CAS: 72509-76-3

Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.
References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)

Formula: C₁₄₁₃C₄H₁₆D₃Cl₂NO₄

Color and Shape: Neat

Molecular weight: 391.24

Ref: TR-F232376

Felodipine - Bio-X ™

CAS: 72509-76-3

Felodipine is a calcium channel blocker and a member of the 1,4-dihydropyridine class of calcium channel blockers that is used to treat high blood pressure and related conditions. Felodipine increases the level of natriuretic peptide in the blood and reduces levels of infectious diseases such as influenza A virus and respiratory syncytial virus (RSV).
Felodipine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₈H₁₉Cl₂NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.25 g/mol

Ref: 3D-BF164445

Felodipine

CAS: 72509-76-3

M06306 - Felodipine

Formula: C₁₈H₁₉Cl₂NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 384.25

Ref: 10-M06306

rac Felodipine-13C4

Controlled Product

CAS: 72509-76-3

Formula: C₄C₁₄H₁₉Cl₂NO₄

Color and Shape: Neat

Molecular weight: 388.224

Ref: TR-F232379

Felodipine

CAS: 72509-76-3

L-type calcium channel blocker; anti-hypertensive

Formula: C₁₈H₁₉Cl₂NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 384.25 g/mol

Ref: 3D-FF23238